Rheumatoid vasculitis
| Rheumatoid vasculitis | |
|---|---|
| Synonyms | |
| Pronounce | N/A |
| Specialty | N/A |
| Symptoms | Skin rash, ulcers, peripheral neuropathy, fever, weight loss |
| Complications | Gangrene, organ damage |
| Onset | Typically occurs in patients with long-standing rheumatoid arthritis |
| Duration | Chronic |
| Types | N/A |
| Causes | Complication of rheumatoid arthritis |
| Risks | Severe rheumatoid arthritis, smoking, male gender |
| Diagnosis | Clinical examination, biopsy, imaging studies |
| Differential diagnosis | Polyarteritis nodosa, Wegener's granulomatosis, microscopic polyangiitis |
| Prevention | Control of rheumatoid arthritis |
| Treatment | Corticosteroids, immunosuppressive drugs |
| Medication | Prednisone, cyclophosphamide, azathioprine |
| Prognosis | Variable, depends on severity and response to treatment |
| Frequency | Rare |
| Deaths | N/A |
Rheumatoid vasculitis is a severe complication of rheumatoid arthritis, characterized by inflammation of the blood vessels (vasculitis). It is a rare condition, affecting less than 5% of people with rheumatoid arthritis.
Symptoms
The symptoms of rheumatoid vasculitis vary depending on the size and location of the affected blood vessels. They may include:
- Skin lesions, such as ulcers, purpura, and necrosis
- Nerve damage, leading to numbness, tingling, or weakness
- Eye problems, such as scleritis and episcleritis
- Heart and lung problems, such as myocardial infarction and pulmonary fibrosis
- Gastrointestinal problems, such as ulcerative colitis and Crohn's disease
Causes
The exact cause of rheumatoid vasculitis is unknown, but it is thought to be related to the chronic inflammation associated with rheumatoid arthritis. Factors that may increase the risk of developing rheumatoid vasculitis include:
- Having severe, long-standing rheumatoid arthritis
- Being a smoker
- Having high levels of rheumatoid factor in the blood
Diagnosis
Rheumatoid vasculitis is diagnosed based on the patient's symptoms, medical history, and physical examination. Additional tests may include:
- Blood tests to check for markers of inflammation and rheumatoid factor
- Imaging tests, such as X-ray, CT scan, and MRI, to check for damage to the blood vessels
- Biopsy of the affected tissue to confirm the diagnosis
Treatment
Treatment for rheumatoid vasculitis aims to reduce inflammation and manage symptoms. This may include:
- Medications, such as corticosteroids, immunosuppressants, and biologics
- Physical therapy to improve strength and mobility
- Surgery to repair damaged blood vessels
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Contributors: Prab R. Tumpati, MD