Nomifensine

Nomifensine (pronunciation: noh-mi-fen-seen) is a type of pharmaceutical drug that was primarily used as an antidepressant and anxiolytic agent. It was developed in the 1960s by the Hoechst AG, a German pharmaceutical company.

Etymology

The term "Nomifensine" is derived from the Latin word 'nomen', meaning 'name', and 'fensine', which is a modification of the word 'phenyl', a chemical structure present in the drug.

Pharmacology

Nomifensine functions by inhibiting the reuptake of dopamine, norepinephrine, and to a lesser extent, serotonin. This increases the concentration of these neurotransmitters in the brain, thereby alleviating symptoms of depression and anxiety.

Medical Uses

Nomifensine was primarily used for the treatment of depression and anxiety disorders. It was also used off-label for the treatment of Parkinson's disease and Attention Deficit Hyperactivity Disorder (ADHD).

Side Effects

Common side effects of Nomifensine include insomnia, dry mouth, nausea, and dizziness. In rare cases, it can cause hemolytic anemia, a condition where the body's immune system destroys its own red blood cells.

Withdrawal

Nomifensine was withdrawn from the market in the late 1980s due to reports of severe side effects, including cases of hemolytic anemia.

See Also

• Antidepressant
• Anxiolytic
• Dopamine
• Norepinephrine
• Serotonin
• Depression
• Anxiety disorders
• Parkinson's disease
• Attention Deficit Hyperactivity Disorder (ADHD)
• Insomnia
• Dry mouth
• Nausea
• Dizziness
• Hemolytic anemia

External links

• Medical encyclopedia article on Nomifensine
• Wikipedia's article - Nomifensine

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