Norfenefrine

Norfenefrine (also known as meta-octopamine, 3-octopamine, or 3,β-dihydroxyphenethylamine) is a cardiovascular drug used in certain countries. It is a norepinephrine analog where the 4-position hydroxyl group has been removed.

Pharmacology

Norfenefrine acts as a norepinephrine-releasing agent. It is a sympathomimetic amine that mimics the actions of the sympathetic nervous system, which includes the release of norepinephrine. Norfenefrine has been found to induce the release of norepinephrine from storage vesicles in the nerve endings into the synaptic cleft, where it acts on adrenergic receptors.

Medical Uses

Norfenefrine is used for the treatment of low blood pressure, especially orthostatic hypotension. It can also be used for the treatment of certain heart conditions, such as chronic heart failure.

Side Effects

Possible side effects of Norfenefrine include palpitations, tachycardia, arrhythmia, and hypertension. It may also cause anxiety, nervousness, and tremors.

Interactions

Norfenefrine may interact with other drugs, such as monoamine oxidase inhibitors (MAOIs), tricyclic antidepressants, and other sympathomimetic amines.

See Also

• Norepinephrine
• Sympathomimetic drug
• Orthostatic hypotension
• Chronic heart failure

References

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Norfenefrine

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  Norfenefrine
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  (R)-Norfenefrine Molecule Ball