Griseofulvin

Griseofulvin

Griseofulvin is a fungistatic agent used to treat superficial fungal skin infections such as tinea capitis and tenia pedis.

Liver safety of Griseofulvin

Griseofulvin therapy can cause transient mild-to-moderate serum aminotransferase elevations and has very rarely been linked to clinically apparent acute drug induced liver injury.

Mechanism of action of Griseofulvin

• Griseofulvin (gris" ee oh ful' vin) is a metabolic product of Penicillium griseofulvum with potent activity against fungal agents.
• Its antifungal activity is believed to be due to disruption of the mitotic spindle of fungal cells, which interferes with cell division.
• Griseofulvin may also inhibit fungal DNA replication.
• Griseofulvin has been used for superficial dermatophyte infections (tinea corporis, tinea capitis, tinea barbae, tinea cruris, tinea pedis or tinea unguium) for many years.

Dosage and administration for Griseofulvin

• The usual recommended dose is 500 to 1000 mg daily depending upon the type and severity of the infection.

Griseofulvin 3 D balls

Rarely used

• Griseofulvin is available in generic forms as tablets of 500 mg, and an oral suspension in several generic forms and under the brand names of Grifulvin V and as film coated tablets of 125 and 250 mg as Gris-PEG.
• Because of the availability of other more potent antifungal agents with a wider sprectum of action, griseofulvin is now rarely used.

Side effects of Griseofulvin

Common side effects include nausea, vomiting and headache.

• Dailymed label info on Griseofulvin
• FDA Griseofulvin