CCL16

CCL16 is a small cytokine belonging to the CC chemokine family that is also known as Chemokine (C-C motif) ligand 16. It is also known by the names HCC-4 (Human CC Chemokine 4), LEC (Liver-expressed chemokine), NCC-4 (Novel CC Chemokine 4), or LCC-1 (Liver-specific CC Chemokine 1).

CCL16 is expressed in the liver, lungs, and certain white blood cells. It is involved in the immune response by attracting immune cells, such as lymphocytes and neutrophils, to sites of inflammation. It is also involved in the formation of blood vessels.

Structure

CCL16 is a protein that is made up of 97 amino acids. It has a molecular weight of approximately 11 kDa. The protein has a typical chemokine fold, with a flexible N-terminal region and a rigid C-terminal helix.

Function

CCL16 attracts various immune cells to sites of inflammation by binding to the chemokine receptors CCR1, CCR2, CCR5 and CCR8. It is also involved in the formation of blood vessels by promoting the migration and proliferation of endothelial cells.

Clinical significance

CCL16 has been implicated in various diseases, including liver disease, lung disease, and certain types of cancer. It is also thought to play a role in the immune response to infection.

See also

• Chemokine
• Cytokine
• Inflammation
• Immune response
• Chemokine receptor

References

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