Leukemia inhibitory factor

From Food & Medicine Encyclopedia

Leukemia inhibitory factor (LIF) is an interleukin 6 class cytokine that affects cell growth by inhibiting differentiation. When LIF levels drop, the cells differentiate.

Function[edit]

LIF is normally expressed in the trophoblast of the uterus and helps prevent the immune system from attacking the developing embryo. Following implantation, LIF also affects bone metabolism, neural development and inflammation.

Clinical significance[edit]

LIF has the capacity to induce terminal differentiation in leukemic cells and other malignant cells, and may have potential use in cancer therapy.

Interactions[edit]

Leukemia inhibitory factor has been shown to interact with LIFR and IL6ST.

See also[edit]

References[edit]

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External links[edit]

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