Leukocyte extravasation
Leukocyte Extravasation
Leukocyte extravasation (pronounced: loo-ko-site ex-tra-va-sa-tion), also known as leukocyte diapedesis or white blood cell migration, is a process in the immune response that allows leukocytes (white blood cells) to exit the bloodstream and enter the tissues where they are needed.
Etymology
The term "leukocyte extravasation" is derived from the Greek words "leukos" (meaning white), "kytos" (meaning cell), and the Latin word "extravasare" (meaning to overflow).
Process
Leukocyte extravasation involves several steps:
- Margination: Leukocytes move to the periphery of the blood vessel.
- Rolling adhesion: Leukocytes roll along the endothelium (inner lining of the blood vessel).
- Tight adhesion: Leukocytes adhere tightly to the endothelium.
- Diapedesis: Leukocytes move through the endothelial cells.
- Migration: Leukocytes move towards the site of infection or inflammation.
Related Terms
- Endothelium: The thin layer of cells that lines the interior surface of blood vessels.
- Inflammation: A protective response involving immune cells, blood vessels, and molecular mediators to remove harmful stimuli.
- Chemotaxis: The movement of an organism or cell in response to a chemical stimulus.
- Integrin: A type of protein involved in cell adhesion and cell-surface mediated signalling.
See Also
External links
- Medical encyclopedia article on Leukocyte extravasation
- Wikipedia's article - Leukocyte extravasation
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