CCL26

CCL26 also known as Eotaxin-3 is a small cytokine belonging to the CC chemokine family that is characterized by two adjacent cysteines. It is produced by certain cells to signal molecules to promote chemotaxis, the movement of cells in response to chemical stimulation. CCL26 is particularly involved in the immune response and plays a role in the chemotaxis of eosinophils, a type of white blood cell that plays a crucial role in the immune system.

Structure

CCL26 is a small protein molecule that is part of the CC chemokine family. This family is characterized by two adjacent cysteines in their amino acid structure. The structure of CCL26 allows it to bind to certain receptors on the surface of cells and initiate a response.

Function

The primary function of CCL26 is to induce chemotaxis in eosinophils, by directing their movement towards the site of inflammation or infection. This is achieved by binding to the CCR3 receptor on the eosinophils. Once bound, it triggers a series of intracellular signals that result in the movement of the eosinophil.

CCL26 also plays a role in the immune response to allergens and has been implicated in conditions such as asthma and atopic dermatitis. It is produced by cells in response to an allergen and attracts eosinophils to the site, leading to inflammation and the symptoms associated with these conditions.

Clinical significance

Due to its role in the immune response, CCL26 has been implicated in a number of inflammatory diseases. High levels of CCL26 have been found in patients with asthma, atopic dermatitis, and eosinophilic esophagitis. This suggests that it may play a role in the pathogenesis of these conditions and could potentially be a target for therapeutic intervention.

See also

• Chemokine
• Cytokine
• Eosinophil
• Asthma
• Atopic dermatitis
• Eosinophilic esophagitis

References

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