Interleukin 28
Interleukin 28 (IL-28), also known as Interferon lambda 2 (IFNλ2), is a type of Cytokine that is involved in the immune response of the body. It is a part of the Interferon family and is produced by dendritic cells, macrophages, and epithelial cells in response to viral infections.
Function
IL-28 has antiviral activity and has been shown to play a crucial role in the immune response against viral infections. It is involved in the activation of the Janus kinase/Signal transducer and activator of transcription (JAK/STAT) signaling pathway, which leads to the expression of antiviral proteins in the cell.
Clinical significance
IL-28 has been implicated in several diseases, including Hepatitis C, Multiple sclerosis, and Psoriasis. It has been shown to have a therapeutic effect in patients with chronic hepatitis C infection. In addition, it has been suggested that IL-28 may play a role in the pathogenesis of multiple sclerosis and psoriasis.
See also
References
External links
- Interleukin 28 at UniProt
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