Epithelioid cell

Epithelioid cell is a type of cell that is found in the body's immune system. These cells are characterized by their epithelial-like appearance, despite being derived from mononuclear phagocytes, a type of white blood cell. Epithelioid cells play a crucial role in the body's immune response, particularly in the formation of granulomas, which are collections of immune cells that form in response to chronic inflammation.

Function

Epithelioid cells are primarily involved in the immune response. They are derived from mononuclear phagocytes, which are a type of white blood cell. When these cells encounter foreign substances or pathogens in the body, they can transform into epithelioid cells. These cells then cluster together to form granulomas, which help to isolate and contain the foreign substance or pathogen.

Structure

Epithelioid cells are characterized by their epithelial-like appearance. They are large, elongated cells with a centrally located nucleus. Despite their appearance, they are not true epithelial cells, but are instead derived from white blood cells.

Clinical significance

Epithelioid cells are often seen in conditions that cause chronic inflammation, such as tuberculosis, sarcoidosis, and Crohn's disease. The presence of these cells can be a sign of an ongoing immune response. In some cases, the formation of granulomas can lead to tissue damage and organ dysfunction.

See also

• Granuloma
• Mononuclear phagocyte system
• Immune response

References

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  Epithelioid cells of mice in the cell culture
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  Epithelioid cells in caseating tuberculous granuloma
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  Epithelioid cells and macrophages in cell culture
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  The outer edge of tuberculosis epithelioid granuloma