CXCL11
CXCL11 is a small cytokine belonging to the CXC chemokine family that is also known as Interferon-inducible T-cell alpha chemoattractant (I-TAC) and Interferon-gamma-inducible protein 9 (IP-9). It is highly expressed in peripheral blood leukocytes, pancreas and liver, with moderate levels in thymus, spleen and lung and low expression levels were in prostate, kidney and ovary.
Function[edit]
CXCL11 attracts activated T cells. It is chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. CXCL11 induces calcium release in activated T-cells and binds to CXCR3. It interacts with glycosaminoglycans (GAGs).
Clinical significance[edit]
CXCL11 has been associated with several diseases, including cancer, HIV, and autoimmune diseases. It is also involved in inflammatory responses and immune responses.
References[edit]
See also[edit]
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