IL36B

IL36B is a protein that in humans is encoded by the IL36B gene. It is a member of the interleukin family, specifically the IL-1 family, and is involved in various immune responses and inflammatory processes.

Function

IL36B, also known as Interleukin-36 beta, is a pro-inflammatory cytokine which plays a crucial role in the immune system. It is primarily expressed in keratinocytes, the predominant cell type in the epidermis, and is involved in the activation of NF-kappaB and MAP kinases. This leads to the production of pro-inflammatory cytokines and chemokines, which contribute to the inflammatory response.

Clinical significance

Alterations in the function or expression of IL36B have been associated with several diseases. For example, mutations in the IL36B gene have been linked to generalized psoriasis, a chronic skin disease characterized by red, scaly patches. In addition, elevated levels of IL36B have been observed in the skin lesions of patients with psoriatic arthritis, suggesting a potential role in the pathogenesis of this condition.

See also

• Interleukin 36
• Interleukin 1 family
• Psoriasis
• Psoriatic arthritis

External links

• IL36B at GeneCards