CCL7
CCL7 is a small cytokine known as a chemokine that is also known as Monocyte-specific chemokine 3 (MCP3). It is utilized by the body's immune system for chemotaxis, or the movement of cells in response to chemical stimuli. CCL7 specifically attracts monocytes, and to a lesser extent lymphocytes, neutrophils, and eosinophils.
Function[edit]
CCL7 is a member of the CC chemokine family, and its gene is located on the third chromosome (3p21) in humans. It is secreted by various cells, including leukocytes and tissue cells, in response to inflammatory signals such as interleukin 1 or lipopolysaccharide.
CCL7 works by binding to several different types of G protein-coupled receptors on the surface of cells, including CCR1, CCR2, and CCR3. This binding triggers a response inside the cell, leading to chemotaxis.
Clinical significance[edit]
CCL7 has been implicated in several disease processes, including rheumatoid arthritis, atherosclerosis, and certain types of cancer. It is thought to contribute to the inflammatory response in these conditions by attracting immune cells to the site of disease.
See also[edit]
References[edit]
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