Interleukin 25

Interleukin 25 (IL-25) is a cytokine that belongs to the IL-17 family. It is also known as IL-17E. IL-25 is produced by Th2 cells, mast cells, and eosinophils, and it plays a crucial role in the immune response, particularly in the context of allergic reactions and autoimmune diseases.

Structure

IL-25 is a member of the IL-17 family, which is composed of six cytokines (IL-17A to IL-17F). IL-25 (IL-17E) is structurally distinct from the other members of the family. It is a 177-amino acid protein with a molecular weight of approximately 20 kDa.

Function

IL-25 induces the production of other cytokines such as IL-4, IL-5, and IL-13 in target cells, which are involved in the Th2 immune response. This response is characterized by the activation of eosinophils, the production of IgE, and the development of airway hyperreactivity, which are all key features of allergic inflammation.

Role in Disease

IL-25 has been implicated in several diseases, including asthma, atopic dermatitis, and eosinophilic esophagitis. It has also been associated with autoimmune diseases such as rheumatoid arthritis and multiple sclerosis.

Therapeutic Potential

Due to its role in the immune response, IL-25 is being investigated as a potential therapeutic target for the treatment of allergic and autoimmune diseases. Inhibiting the activity of IL-25 may help to reduce the severity of these conditions.

See Also

• Interleukin
• Cytokine
• Type 2 helper cell
• Mast cell
• Eosinophil
• Allergic reaction
• Autoimmune disease

References

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