CCL21

CCL21 is a small cytokine belonging to the CC chemokine family that is also known as 6Ckine (because it has six conserved cysteine residues), exodus-2, and secondary lymphoid-tissue chemokine (SLC). The chemokine CCL21 is involved in the function of the immune system, specifically in the migration of leukocytes in secondary lymphoid organs.

Structure

CCL21 is a small protein molecule that is part of the CC chemokine family. It is characterized by having six conserved cysteine residues, which is why it is also known as 6Ckine. The structure of CCL21 is important for its function in the immune system.

Function

CCL21 plays a crucial role in the immune system. It is involved in the migration of leukocytes in secondary lymphoid organs. This chemokine attracts dendritic cells, T cells, and B cells by interacting with a cell surface chemokine receptor known as CCR7.

Clinical significance

CCL21 has been implicated in various diseases and conditions. It is involved in the pathogenesis of inflammatory and autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. It is also involved in the progression of certain types of cancer, including lung cancer and melanoma.

See also

• Chemokine
• Cytokine
• Leukocyte
• Lymphoid organs
• Dendritic cells
• T cells
• B cells
• CCR7
• Rheumatoid arthritis
• Multiple sclerosis
• Lung cancer
• Melanoma