Interleukin 26

Interleukin 26 (IL-26) is a cytokine that is part of the interleukin family, specifically the IL-10 subfamily. It is encoded by the IL26 gene in humans and is involved in inflammatory and immune responses.

Function

IL-26 is produced by T cells, particularly Th17 cells, in response to infection or inflammation. It acts on various cell types, including epithelial cells, endothelial cells, and monocytes, to induce the production of pro-inflammatory cytokines and chemokines. This leads to the recruitment and activation of neutrophils, enhancing the immune response.

Role in Disease

IL-26 has been implicated in several diseases, including rheumatoid arthritis, psoriasis, and inflammatory bowel disease. It is thought to contribute to the pathogenesis of these diseases by promoting inflammation and tissue damage.

Therapeutic Potential

Due to its role in inflammation and immune responses, IL-26 is being investigated as a potential therapeutic target for inflammatory and autoimmune diseases. Inhibiting IL-26 activity could potentially reduce inflammation and tissue damage in these conditions.

See Also

• Interleukin
• Cytokine
• Inflammation
• Immune response