CCL23

CCL23 (Chemokine (C-C motif) ligand 23), also known as MPIF-1 (Myeloid Progenitor Inhibitory Factor 1), is a small cytokine belonging to the CC chemokine family that is also known as CK-beta-8. This chemokine is secreted by activated monocytes and macrophages and is chemotactic for resting T cells and monocytes.

Function

CCL23 is involved in immune responses and inflammation. It is secreted by activated monocytes and macrophages and is chemotactic for resting T cells and monocytes. The gene for CCL23 is located on human chromosome 17 within a large cluster of other chemokines.

Clinical significance

CCL23 has been implicated in several diseases, including rheumatoid arthritis, asthma, and atherosclerosis. It is also involved in the recruitment of monocytes into the arterial wall, which is a key event in the pathogenesis of atherosclerosis.

Interactions

CCL23 has been shown to interact with chemokine receptors such as CCR1 and CCR3. These interactions play a crucial role in the chemotactic properties of CCL23.

See also

• Chemokine
• Cytokine
• Monocyte
• Macrophage
• T cell
• Chemokine receptor
• Rheumatoid arthritis
• Asthma
• Atherosclerosis

References

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