Interferon type II

Interferon Type II

Interferon Type II (in-ter-feer-on type two, /ˌɪntərˈfɪərɒn taɪp tuː/), also known as IFN-γ, is a type of Interferon that is critical for innate and adaptive immunity against viral and intracellular bacterial infections and for tumor control.

Etymology

The term "Interferon" was coined by Alick Isaacs and Jean Lindenmann in 1957. It is derived from the ability of these proteins to "interfere" with viral replication. The "Type II" designation is a classification based on the protein's structure and response to viral infections.

Function

Interferon Type II is secreted by T cells and Natural Killer cells in response to antigen stimulation, particularly from Interleukin 12 (IL-12) from macrophages. It plays a crucial role in the body's defense against viral and microbial pathogens by promoting the phagocytic activity of macrophages and enhancing the cytotoxic activity of Natural Killer cells.

Related Terms

• Interferon
• T cells
• Natural Killer cells
• Antigen
• Interleukin 12
• Macrophages
• Phagocytic activity
• Cytotoxic activity

External links

• Medical encyclopedia article on Interferon type II
• Wikipedia's article - Interferon type II

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