IFNA4

IFNA4 is a protein that in humans is encoded by the IFNA4 gene. The protein encoded by this gene is a member of the interferon family. Interferons are proteins released by host cells in response to the presence of pathogens such as viruses, bacteria, parasites or tumor cells. They allow for communication between cells to trigger the protective defenses of the immune system that eradicate pathogens or tumors.

Function

Interferons belong to the large class of glycoproteins known as cytokines. Interferons are produced by a wide variety of cells in response to the presence of double-stranded RNA, a key indicator of viral infection. Interferons assist the immune response by inhibiting viral replication within host cells, activating natural killer cells and macrophages, increasing antigen presentation to lymphocytes, and inducing the resistance of host cells to viral infection.

Clinical significance

The IFNA4 gene has been associated with the onset of various diseases. For instance, it has been linked to hepatitis C infection, autoimmune diseases, and certain types of cancer.

See also

• Interferon
• Cytokines
• Immune system
• Pathogen

References

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External links

• IFNA4 at the US National Library of Medicine Medical Subject Headings (MeSH)