Interleukin 33
Interleukin 33 (IL-33) is a protein that in humans is encoded by the IL33 gene. IL-33 is a member of the interleukin family of cytokines that are involved in the immune response.
Function
IL-33 is a cytokine that binds to the ST2 receptor (a member of the Toll-like receptor superfamily) and is known to drive production of other cytokines (such as IL-4, IL-5, and IL-13) that induce T-helper cell type 2 (Th2) responses. It is expressed by various cell types, including fibroblasts, mast cells, and dendritic cells, and can be released upon cell death.
Clinical significance
IL-33 has been implicated in a variety of diseases, including asthma, rheumatoid arthritis, and cardiovascular disease. It is thought to play a role in the pathogenesis of these diseases by promoting inflammation and tissue damage.
See also
References
External links
- IL33 gene at NCBI
- IL-33 protein at UniProt
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