IL17RA: Difference between revisions

Latest revision as of 20:33, 30 December 2024

Interleukin-17 receptor A (IL17RA) is a protein that in humans is encoded by the IL17RA gene. This receptor is a part of the interleukin-17 receptor family and plays a crucial role in immune responses.

Function[edit]

IL17RA is a type I transmembrane protein that binds to interleukin 17 (IL-17), a cytokine produced by activated T cells. The binding of IL-17 to IL17RA triggers a signaling cascade that leads to the activation of NF-kB and mitogen-activated protein kinase (MAPK) pathways, which are important for the inflammatory response.

Clinical significance[edit]

Mutations in the IL17RA gene can lead to immune system disorders, as the receptor is essential for the proper functioning of the immune system. Dysregulation of IL17RA signaling has been implicated in autoimmune diseases such as psoriasis, rheumatoid arthritis, and multiple sclerosis.

Interactions[edit]

IL17RA interacts with several other proteins to mediate its effects. It forms a complex with IL17RC to bind IL-17A and IL-17F, which are key cytokines in the inflammatory response. This receptor complex is critical for the downstream signaling that leads to the production of pro-inflammatory cytokines.

References[edit]

External links[edit]

@@ Line 1: / Line 1: @@
-'''IL17RA''' is a human gene that encodes for the Interleukin 17 receptor A. This receptor is a part of the [[interleukin-17 receptor]] family, a group of receptors that play a crucial role in inflammatory responses and in the development of certain diseases such as [[rheumatoid arthritis]] and [[psoriasis]].
-== Function ==
+{{Infobox protein
-The IL17RA gene is responsible for the production of the IL17RA protein, which is a part of the [[cytokine]] receptor family. This protein is a receptor for [[interleukin 17A]], [[interleukin 17F]], and [[interleukin 25]]. It plays a vital role in mediating the inflammatory response, including the activation of the [[NF-kappa B]] pathway.
+| name = Interleukin-17 receptor A
+| image = <!-- Image removed -->
+| caption = <!-- Caption removed -->
+| HGNCid = 5981
+| symbol = IL17RA
+| alt_symbols = IL17R
+| EntrezGene = 23765
+| OMIM = 605461
+| RefSeq = NM_014339
+| UniProt = Q96F46
+| PDB = 3JVF
+}}
-== Clinical Significance ==
+'''Interleukin-17 receptor A''' ('''IL17RA''') is a [[protein]] that in humans is encoded by the '''IL17RA''' [[gene]]. This receptor is a part of the [[interleukin-17 receptor]] family and plays a crucial role in [[immune response]]s.
-Mutations in the IL17RA gene have been associated with several diseases. For instance, a deficiency in IL17RA can lead to [[chronic mucocutaneous candidiasis]], a condition characterized by persistent and recurrent infections of the skin, nails, and mucous membranes.
-Furthermore, the IL17RA gene has been implicated in the pathogenesis of autoimmune diseases such as [[rheumatoid arthritis]] and [[psoriasis]]. Studies have shown that blocking the IL17RA receptor can help reduce inflammation and disease activity in these conditions.
+== Function ==
+IL17RA is a type I [[transmembrane protein]] that binds to [[interleukin 17]] (IL-17), a [[cytokine]] produced by activated [[T cells]]. The binding of IL-17 to IL17RA triggers a signaling cascade that leads to the activation of [[NF-kB]] and [[mitogen-activated protein kinase]] (MAPK) pathways, which are important for the inflammatory response.
-== Research ==
+== Clinical significance ==
-Research into the IL17RA gene and its associated protein continues to be a significant area of interest in the field of [[immunology]]. Understanding the role of this gene in the immune response and disease development may lead to the development of new therapeutic strategies for a variety of conditions.
+Mutations in the IL17RA gene can lead to [[immune system disorders]], as the receptor is essential for the proper functioning of the immune system. Dysregulation of IL17RA signaling has been implicated in [[autoimmune diseases]] such as [[psoriasis]], [[rheumatoid arthritis]], and [[multiple sclerosis]].
-[[File:IL17RA gene location.png|thumb|right|300px|Location of the IL17RA gene on chromosome 22.]]
+== Interactions ==
+IL17RA interacts with several other proteins to mediate its effects. It forms a complex with [[IL17RC]] to bind IL-17A and IL-17F, which are key cytokines in the inflammatory response. This receptor complex is critical for the downstream signaling that leads to the production of [[pro-inflammatory cytokines]].
-== See Also ==
+== See also ==
-* [[Interleukin 17]]
+* [[Interleukin-17]]
-* [[Interleukin 17 receptor]]
+* [[Cytokine receptor]]
-* [[Cytokine]]
+* [[Autoimmune disease]]
-* [[NF-kappa B]]
-* [[Chronic mucocutaneous candidiasis]]
-* [[Rheumatoid arthritis]]
-* [[Psoriasis]]
 == References ==
 <references />
-{{medicine-stub}}
+== External links ==
+* [https://www.ncbi.nlm.nih.gov/gene/23765 IL17RA gene - NCBI]
+* [https://www.uniprot.org/uniprot/Q96F46 IL17RA protein - UniProt]
+{{Cytokines}}
+{{Receptors}}
-[[Category:Genes]]
+[[Category:Human proteins]]
-[[Category:Immunology]]
+[[Category:Immune system]]
-[[Category:Rheumatology]]
+[[Category:Receptors]]
-[[Category:Dermatology]]
+[[Category:Genes on human chromosome 22]]