Yellow nail syndrome

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Yellow nail syndrome
Yellow nail syndrome
Synonyms	N/A
Pronounce	N/A
Specialty	N/A
Symptoms	Yellow nails, lymphedema, pleural effusion
Complications	Respiratory tract infections, bronchiectasis
Onset	Usually in adulthood
Duration	Chronic
Types	N/A
Causes	Unknown, possibly genetic
Risks	Lymphedema, chronic respiratory conditions
Diagnosis	Clinical evaluation, nail biopsy
Differential diagnosis	Onychomycosis, psoriasis, chronic bronchitis
Prevention	N/A
Treatment	Vitamin E, corticosteroids, antibiotics
Medication	N/A
Prognosis	Variable, often chronic
Frequency	Rare
Deaths	N/A

Yellow nail syndrome, also known as "primary lymphedema associated with yellow nails and pleural effusion"

Yellow nail syndrome

Other Names

Lymphedema with yellow nails; YNS

Characteristics

Yellow nail syndrome is a very rare disorder characterized by three features:

1. yellow nail discoloration,
2. respiratory problems, and
3. lower limb swelling (lymphedema).

Demographics

It usually occurs in people over age 50, but can occur in younger people.

Clinical features

In addition to being yellow, nails may lack a cuticle, grow very slowly, and become detached (onycholysis). Respiratory problems may include chronic cough, bronchiectasis, and pleural effusion. Chronic sinusitis may also occur. The cause of yellow nail syndrome remains unknown. It usually occurs on its own, but is sometimes associated with autoimmune disease, lymphatic diseases, or cancers. Some researchers have hypothesized that titanium may play a role in the development of yellow nail syndrome (for example, in dental or joint implants or other environmental exposures). Treatment addresses each symptom present. In some cases, yellow nail syndrome goes away on its own.

Signs and symptoms

80%-99% of people have these symptoms

• Bronchiectasis
• Fingernail dysplasia
• Hypoplasia of lymphatic vessels
• Lymphedema
• Toenail dysplasia or Yellow nails

30%-79% of people have these symptoms

• Cough
• Dyspnea
• Pleuritis
• Recurrent respiratory infections
• Rhinitis
• Sinusitis

5%-29% of people have these symptoms

• Biliary tract neoplasm
• Generalised abnormality of skin
• Immunodeficiency
• Neoplasm of the lung
• Nephropathy
• Onycholysis or detachment of nail
• Pulmonary arterial hypertension
• Renal neoplasm
• Sarcoma

Cause

• The exact cause of yellow nail syndrome remains unknown. Lymphatic impairment or reduced lymphatic drainage has been proposed, as it may explain lymphedema, pleural effusion, and nail discoloration.
• However, problems with the lymphatic system are not known to cause bronchiectasia and sinusitis.
• Additionally, lymphatic impairment is not easy to confirm.
• While most cases of yellow nail syndrome occur randomly, a few cases have run in families.
• Although this suggests that genetic factors may play a role in some cases, no known genetic factors have been identified.

Rarely, yellow nail syndrome has occurred in people with autoimmune disease, lymphatic diseases, or cancers.

Diagnosis

Making a diagnosis for a genetic or rare disease can often be challenging. Medical history, symptoms, physical exam, and laboratory test results are important in order to make a diagnosis.

Testing

• Pulmonary function testing can show obstruction of the airways.
• People with pleural effusions may show evidence of restriction in lung volumes due to the fluid.
• Analysis of the fluid in pleural effusions generally shows high levels of protein but low levels of cholesterol and lactate dehydrogenase, but about 30% of effusions are chylous (chylothorax) in that they have the characteristics of lymph.
• A lymphogram may be performed in people with lymphedema.
• This can show both under developed (hypoplastic) lymphatic ducts and dilated ducts.
• Dye may be found in the skin months after the initial test.
• Scintigraphy of lymph flow (lymphoscintigraphy) shows delays in drainage of lymph (sometimes asymmetrically), although this test can also be normal.

Treatment

• Yellow nail syndrome management aims to address each of the symptoms.
• Treatment for nail discoloration may include oral vitamin E and/or triazole antifungals.
• Pleural effusion may be treated with surgery.
• Antibiotic prophylaxis may be prescribed for bronchiectasia with chronic mucus production.
• Lymphedema treatment may involve low-stretch bandages and elastic compression garments combined with skin care, exercises and manual lymph drainage as needed.
• In some cases, yellow nail syndrome goes away on its own or when an underlying, associated condition is treated.

Genetics

Although it has been described in families, it has been suggested that it might not have a genetic link.

Prognosis

People with yellow nail syndrome have been found to have a moderately reduced lifespan compared to people without the condition.

Epidemiology

The condition is thought to be rare, with approximately 150 cases described in the medical literature.

Patient Registry

• Research is needed to determine the cause of YNS, to identify biomarkers for diagnosis, prognosis and response to therapy, and to find effective treatments.
• Patients, families, and caregivers are encouraged to join the NIH Rare Lung Diseases Consortium Contact Registry.

History

The condition was first described in 1964 by London physicians Peter Samman and William White.

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