Spindle poison

Other names

The term spindle poison is also known as a spindle toxin.

Definition

It is a poison that disrupts cell division by affecting the protein threads that connect the centromere regions of chromosomes, known as spindles.

Effects

Spindle poisons effectively cease the production of new cells by interrupting the mitosis phase of cell division at the spindle assembly checkpoint (SAC).

Limitations

However, Spindle poisons are not yet 100% effective at ending the formation of tumors (neoplasms).

Role in Chemotherapy

Although not 100% effective, substantive therapeutic efficacy has been found in these types of chemotherapeutic treatments. 

Mitotic spindle

The mitotic spindle is composed of microtubules (polymerized tubulin) that aid, along with regulatory proteins; each other in the activity of appropriately segregating replicated chromosomes.

Example spindle poisons

• Examples of spindle poisons include paclitaxel and vinblastine

Other examples include:

• Mebendazole
• Colchicine
• Griseofulvin
• [[Vinca alkaloid

Mechanism of action

• They exert their potent anti-neoplastic effects through activation of the spindle assembly checkpoint (SAC), thus arresting cells in mitosis.

Non-responders

• Unfortunately, only certain cancers are susceptible to these drugs, and many patients fail to respond to treatment.

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