Nedaplatin

Nedaplatin

Nedaplatin is a platinum-based chemotherapy drug used in the treatment of various types of cancer, including lung cancer, esophageal cancer, and cervical cancer. It is a second-generation platinum compound with a similar mechanism of action to cisplatin, but with less toxicity and fewer side effects.

History

Nedaplatin was developed by Shionogi in Japan and was first approved for use in 1995. It was designed to overcome the limitations of cisplatin, particularly its high toxicity and resistance.

Mechanism of Action

Nedaplatin works by interfering with the DNA in cancer cells, preventing them from dividing and growing. It forms covalent bonds with the DNA, causing the DNA strands to cross-link and inhibiting DNA synthesis and function. This leads to cell death and the reduction of the tumor.

Uses

Nedaplatin is used in the treatment of various types of cancer. It is often used in combination with other chemotherapy drugs to increase its effectiveness. The types of cancer it is used to treat include:

• Lung cancer
• Esophageal cancer
• Cervical cancer
• Head and neck cancer

Side Effects

Like all chemotherapy drugs, Nedaplatin can cause side effects. These can vary from person to person and depend on the dosage and length of treatment. Common side effects include:

• Nausea and vomiting
• Fatigue
• Hair loss
• Anemia
• Neutropenia (low white blood cell count)

See Also

• Chemotherapy
• Cisplatin
• Cancer treatment

References

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