Lisocabtagene maraleucel
Lisocabtagene Maraleucel
Lisocabtagene Maraleucel (pronounced as li-so-kab-TA-jeen mar-a-LOO-sel) is a type of immunotherapy used in the treatment of certain types of B-cell lymphoma, including diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL). It is a chimeric antigen receptor (CAR) T-cell therapy, which involves modifying a patient's own T cells to fight cancer cells.
Etymology
The name Lisocabtagene Maraleucel is derived from the following components: 'Liso-' is a prefix used in pharmacology to denote a product of Bristol-Myers Squibb, the company that developed the drug. 'cabtagene' refers to the CAR T-cell gene modification, and 'maraleucel' indicates that the drug targets the CD19 antigen on B cells ('mara-' from the Latin 'mare' meaning 'sea', metaphorically representing the B-cell surface, and '-leucel' from 'leukocyte', a type of white blood cell).
Usage
Lisocabtagene Maraleucel is used for the treatment of adult patients with relapsed or refractory large B-cell lymphoma after two or more lines of systemic therapy, including DLBCL not otherwise specified, high grade B-cell lymphoma, primary mediastinal large B-cell lymphoma, and FL grade 3B.
Mechanism of Action
Lisocabtagene Maraleucel works by modifying the patient's T cells to express a chimeric antigen receptor that targets the CD19 antigen, a protein on the surface of B cells. This allows the T cells to recognize and kill the B cells, which are often cancerous in patients with B-cell lymphoma.
Related Terms
- Chimeric Antigen Receptor T-Cell Therapy: A type of treatment that modifies the patient's own T cells to fight cancer cells.
- B-cell Lymphoma: A type of cancer that forms in B cells.
- Diffuse Large B-cell Lymphoma: The most common type of non-Hodgkin lymphoma in adults.
- Follicular Lymphoma: A type of blood cancer. It is a form of B-cell lymphoma that is usually slow-growing.
External links
- Medical encyclopedia article on Lisocabtagene maraleucel
- Wikipedia's article - Lisocabtagene maraleucel
This WikiMD article is a stub. You can help make it a full article.
Languages: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
Urdu,
বাংলা,
తెలుగు,
தமிழ்,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
European
español,
Deutsch,
français,
русский,
português do Brasil,
Italian,
polski