Bisantrene

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Bisantrene

Bisantrene (pronunciation: bih-SAN-treen) is a synthetic, anthracene-based, antineoplastic agent. It is primarily used in the treatment of acute myeloid leukemia (AML).

Etymology

The term "Bisantrene" is derived from the Greek words "bis" meaning "twice" and "anthrakitis" meaning "coal-like", referring to its anthracene base.

Usage

Bisantrene has been used in clinical trials for the treatment of acute myeloid leukemia (AML). It is known to intercalate into DNA, disrupting its function and leading to cell death. It is less cardiotoxic than other anthracycline drugs, making it a potential alternative for patients who cannot tolerate these treatments.

Related Terms

  • Anthracycline: A class of drugs that are among the most powerful chemotherapy drugs invented. Bisantrene is a non-anthracycline drug that has similar effects but is less cardiotoxic.
  • Cardiotoxicity: The occurrence of heart electrophysiology dysfunction or muscle damage. The heart becomes weaker and is not as efficient in pumping and therefore circulating blood.
  • Acute Myeloid Leukemia (AML): A cancer of the myeloid line of blood cells, characterized by the rapid growth of abnormal cells that build up in the bone marrow and blood and interfere with normal blood cells.

See Also

External links

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