Carmofur
Carmofur
Carmofur (pronounced: /ˈkɑːrmoʊfɜːr/) is a pyrimidine analogue used as an antineoplastic agent. It is a derivative of fluorouracil, a type of chemotherapy drug.
Etymology
The term "Carmofur" is derived from the chemical name N-carbamoyl-5-fluorouracil. The "-fur" suffix is common in many fluoropyrimidine drugs.
Usage
Carmofur is used in the treatment of various types of cancer, including breast cancer, colorectal cancer, and gastric cancer. It works by inhibiting the enzyme thymidylate synthase, which is necessary for DNA replication and repair. This inhibition leads to DNA damage and cell death in rapidly dividing cancer cells.
Side Effects
Like many chemotherapy drugs, Carmofur can have several side effects. These may include nausea, vomiting, diarrhea, and neutropenia. It can also cause hand-foot syndrome, a condition characterized by redness, swelling, and pain in the hands and feet.
Related Terms
- Fluorouracil: A chemotherapy drug from which Carmofur is derived.
- Thymidylate synthase: The enzyme inhibited by Carmofur.
- Hand-foot syndrome: A potential side effect of Carmofur treatment.
External links
- Medical encyclopedia article on Carmofur
- Wikipedia's article - Carmofur
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