Tioguanine
Tioguanine
Tioguanine (pronounced tee-oh-gwah-neen), also known as thioguanine or 6-thioguanine (6-TG), is a medication used in the treatment of acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), and chronic myeloid leukemia (CML). It is a type of chemotherapy drug that belongs to the class of medications known as purine analogues.
Etymology
The term "Tioguanine" is derived from the Greek words "thio" meaning "sulfur" and "guanine" which is one of the four main nucleobases found in the nucleic acids DNA and RNA.
Usage
Tioguanine works by interfering with the growth of cancer cells, which helps to slow or stop the spread of cancer. It is usually given as part of a combination chemotherapy regimen.
Side Effects
Common side effects of tioguanine include nausea, vomiting, diarrhea, and mouth sores. More serious side effects can include bone marrow suppression, liver toxicity, and skin rash.
Related Terms
- Leukemia: A type of cancer that affects the blood and bone marrow.
- Chemotherapy: A type of cancer treatment that uses drugs to kill cancer cells.
- Purine analogue: A type of drug that mimics the structure of purines, which are components of DNA.
See Also
- Acute myeloid leukemia
- Acute lymphoblastic leukemia
- Chronic myeloid leukemia
- Chemotherapy
- Purine analogue
External links
- Medical encyclopedia article on Tioguanine
- Wikipedia's article - Tioguanine
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