Proteasome inhibitor

Proteasome inhibitors (pronunciation: pro-tee-uh-sohm in-hib-i-tors) are a type of drug that blocks the action of proteasomes, complex protein structures in cells that break down other proteins.

Etymology

The term "proteasome inhibitor" is derived from the words "proteasome", which refers to a protein complex within cells that degrades unneeded or damaged proteins, and "inhibitor", which refers to a substance that slows down or prevents a particular chemical reaction.

Function

Proteasome inhibitors work by blocking the proteasome's ability to break down proteins. This can lead to an accumulation of proteins in the cell, which can trigger cell death. This property makes proteasome inhibitors useful in the treatment of certain types of cancer, as they can induce death in cancer cells.

Examples

Examples of proteasome inhibitors include Bortezomib, Carfilzomib, and Ixazomib. These drugs are used in the treatment of multiple myeloma, a type of blood cancer.

Related Terms

Proteasome: A protein complex within cells that degrades unneeded or damaged proteins.
Cancer: A group of diseases characterized by the uncontrolled growth and spread of abnormal cells.
Bortezomib: A proteasome inhibitor used in the treatment of multiple myeloma.
Carfilzomib: A proteasome inhibitor used in the treatment of multiple myeloma.
Ixazomib: A proteasome inhibitor used in the treatment of multiple myeloma.

External links

Medical encyclopedia article on Proteasome inhibitor
Wikipedia's article - Proteasome inhibitor

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Proteasome inhibitor