Purine analogue
Purine analogue is a type of drug that mimics the structure of metabolic purines. They are used in the treatment of cancer and inflammatory disorders.
Overview[edit]
Purine analogues are a group of antimetabolites which mimic the structure of metabolic purines and are used in the treatment of leukemia and lymphoma. They interfere with DNA and RNA synthesis by inhibiting the enzyme needed for purine production. This inhibition prevents cell division and leads to cell death, particularly in rapidly dividing cells such as cancer cells.
Types of Purine Analogues[edit]
There are several types of purine analogues that include mercaptopurine, fludarabine, cladribine, pentostatin, and nelarabine. Each of these drugs has a slightly different effect on the cell cycle and is used to treat different types of cancers.
Mercaptopurine[edit]
Mercaptopurine is a purine analogue that interferes with nucleic acid synthesis and is used to treat acute lymphoblastic leukemia.
Fludarabine[edit]
Fludarabine is a purine analogue that is used in the treatment of chronic lymphocytic leukemia and non-Hodgkin lymphoma. It works by interfering with DNA synthesis.
Cladribine[edit]
Cladribine is a purine analogue used to treat hairy cell leukemia by interfering with DNA synthesis.
Pentostatin[edit]
Pentostatin is a purine analogue that inhibits an enzyme called adenosine deaminase, which is important in DNA synthesis and repair. It is used to treat hairy cell leukemia.
Nelarabine[edit]
Nelarabine is a purine analogue used in the treatment of T-cell acute lymphoblastic leukemia and T-cell lymphoblastic lymphoma.
Side Effects[edit]
Like all chemotherapy drugs, purine analogues can have side effects. These can include nausea, vomiting, diarrhea, and myelosuppression where the bone marrow's ability to produce blood cells is decreased.
See Also[edit]
This Chemotherapy related article is a stub. You can help WikiMD by expanding it.
 | This medical article is a stub. You can help Wikipedia by adding missing information. |
-
Purine_analogue -
Mercaptopurine -
Tioguanine -
Fludarabine phosphate
Ad. Transform your health with W8MD Weight Loss, Sleep & MedSpa
Tired of being overweight?
Special offer:
Budget GLP-1 weight loss medications
- Semaglutide starting from $29.99/week and up with insurance for visit of $59.99 and up per week self pay.
- Tirzepatide starting from $45.00/week and up (dose dependent) or $69.99/week and up self pay
✔ Same-week appointments, evenings & weekends ✔ Tele visits available with certain limitations Learn more:
- GLP-1 weight loss clinic NYC
- W8MD's NYC medical weight loss
- W8MD Philadelphia GLP-1 shots
- Philadelphia GLP-1 injections
- Affordable GLP-1 shots NYC
- Budget GLP-1 shots
|
WikiMD Medical Encyclopedia |
Medical Disclaimer: WikiMD is for informational purposes only and is not a substitute for professional medical advice. Content may be inaccurate or outdated and should not be used for diagnosis or treatment. Always consult your healthcare provider for medical decisions. Verify information with trusted sources such as CDC.gov and NIH.gov. By using this site, you agree that WikiMD is not liable for any outcomes related to its content. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
