Topotecan

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Topotecan (pronunciation: /ˌtoʊpəˈtiːkæn/) is a chemotherapeutic agent that is used in the treatment of various types of cancer. It is a derivative of camptothecin, a natural product extracted from the Chinese tree Camptotheca acuminata.

Etymology

The name "Topotecan" is derived from its chemical structure, which is a topoisomerase I inhibitor, and its origin, which is a derivative of camptothecin. The "-can" suffix is common in the names of chemotherapeutic agents.

Pharmacology

Topotecan works by inhibiting the enzyme topoisomerase I, which is necessary for DNA replication. By inhibiting this enzyme, topotecan prevents cancer cells from replicating their DNA and thus inhibits their growth and proliferation.

Uses

Topotecan is used in the treatment of various types of cancer, including ovarian cancer, cervical cancer, and small cell lung cancer. It is often used in combination with other chemotherapeutic agents.

Side Effects

Common side effects of topotecan include nausea, vomiting, diarrhea, and myelosuppression, which can lead to anemia, neutropenia, and thrombocytopenia.

See Also

External links

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