Leukodystrophy

Group of disorders characterised by degeneration of white matter in the brain

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Leukodystrophies are a group of usually inherited disorders characterized by degeneration of the white matter in the brain.<ref name="SachdevKeshavan2010">,

 Secondary Schizophrenia. online version, 
  
 Cambridge University Press, 
  
  
  
 ISBN 978-0-521-85697-3, 
  
  
  
 Pages: 241–,</ref> The word leukodystrophy comes from the Greek roots leuko, "white", dys, "abnormal" and troph, "growth". The leukodystrophies are caused by imperfect growth or development of the myelin sheath, the fatty insulating covering around nerve fibers.<ref> One or more of the preceding sentences incorporates text from a work  in the public domain: "Leukodystrophy Information Page". National Institute of Neurological Disorders and Stroke. 25 May 2017. Retrieved 18 March 2018.

</ref> Leukodystrophies may be classified as hypomyelinating or demyelinating diseases, depending on whether the damage is present before birth or occurs after. Other demyelinating diseases are usually not congenital and have a toxic or autoimmune cause.<ref> </ref>

When damage occurs to white matter, immune responses can lead to inflammation in the central nervous system (CNS), along with loss of myelin. The degeneration of white matter can be seen in an MRI scan and used to diagnose leukodystrophy. Leukodystrophy is characterized by specific symptoms including decreased motor function, muscle rigidity, and eventual degeneration of sight and hearing. While the disease is fatal, the age of onset is a key factor, as infants have a typical life expectancy of 2–8 years, while adults typically live more than a decade after onset. Treatment options are limited, although hematopoietic stem cell transplantations using bone marrow or cord blood seem to help in certain types while further research is being done.

The combined incidence of the leukodystrophies is estimated at 1 in 7,600.<ref>,

 The burden of inherited leukodystrophies in children, 
 Neurology, 
 
 Vol. 75(Issue: 8),
 pp. 718–725,
 DOI: 10.1212/WNL.0b013e3181eee46b,
 PMID: 20660364,
 PMC: 2931652,</ref> The majority of types involve the inheritance of an X-linked recessive, or X-linked dominant trait, while others, although involving a defective gene, are the result of spontaneous mutation rather than genetic inheritance.

Symptoms and signs

Some specific symptoms vary from one type of leukodystrophy to the next, but the vast majority of symptoms are shared as the causes for the disease generally have the same effects. Symptoms are dependent on the age of onset, which is predominantly in infancy and early childhood, although the exact time of onset may be difficult to determine. Hyperirritability and hypersensitivity to the environment are common, as well as some tell-tale physical signs including muscle rigidity and a backwards-bent head.<ref name="Krabbe disease">,

 History, genetic, and recent advances on Krabbe disease, 
 Gene, 
 
 Vol. 555(Issue: 1),
 pp. 2–13,
 DOI: 10.1016/j.gene.2014.09.046,
 PMID: 25260228,</ref> Botox therapy is often used to treat patients with spasticity.<ref>, 
 Tardive dystonia and its treatment, 
 Journal of Psychiatry and Neuroscience, 
 2003,
 Vol. 28(Issue: 3),
 
 
 
 PMC: 161748,</ref> Juvenile and adult onsets display similar symptoms including a decrease or loss in hearing and vision. While children do experience optic and auditory degeneration, the course of the disease is usually too rapid, causing death relatively quickly, whereas adults may live with these conditions for many years. In children, spastic activity often precedes progressive ataxia and rapid cognitive deterioration which has been described as mental retardation.<ref name="Chinese article">, 
 [A family with two children diagnosed with aspartylglucosaminuria-case report and literature review]., 
 Zhonghua Er Za Zhi, 
 
 Vol. 52(Issue: 6),
 pp. 455–9,
 
 PMID: 25190167,</ref> Epilepsy is commonplace for patients of all ages.<ref name="Spanish population">, 
 Vanishing white matter disease in a Spanish population., 
 J Cent Nerv Syst Dis., 
 
 Vol. 6,
 pp. 59–68,
 DOI: 10.4137/JCNSD.S13540,
 PMID: 25089094,
 PMC: 4116383,</ref> More progressed patients show weakness in deglutition, leading to spastic coughing fits due to inhaled saliva. Classic symptomatic progression of juvenile X-linked adrenoleukodystrophy is shown in the 1992 film, Lorenzo's Oil.<ref name="Lorenzos Oil">

Rubin, Rita. Forbes.com: Lorenzo's Oil Could Not Cure Lorenzo, But Newborn Screening Is Expected To Save Others From His Fate(link). Forbes.com.

March 13, 2016.

Accessed July 31, 2018.

.</ref>

Course and timetable are dependent on the age of onset with infants showing a lifespan of 2–8 years, juveniles 2–10 years and adults typically 10+ years. Adults typically see an extended period of stability followed by a decline to a vegetative state and death.<ref name="Krabbe disease" /> While treatments do exist, most are in the experimental phase and can only promise a halt in the progression of symptoms, although some gene therapies have shown some symptomatic improvement.<ref name=Biffi/> The debilitating course of the disease has led to numerous philosophical and ethical arguments over experimental clinical trials, patients’ rights and physician-assisted suicide.<ref name=Ethics>,

 Ethical management in the constitution of a European database for leukodystrophies rare diseases., 
 Eur J Paediatr Neurol., 
 
 Vol. 18(Issue: 5),
 pp. 597–603,
 DOI: 10.1016/j.ejpn.2014.04.002,
 PMID: 24786336,
 
 
 Full text,</ref>

Causes

While the more specific underlying causes of leukodystrophy are dependent upon the type, there are, however, common pathophysiological patterns that can be seen amongst all types. First and foremost, leukodystrophy is a neurodegenerative disease that is always the result of both impairment and maintenance of myelin sheaths surrounding neuronal axons in the central nervous system as the result of a genetic mutation.<ref>,

 Imaging manifestations of the leukodystrophies, inherited disorders of white matter., 
 Radiologic Clinics of North America, 
 
 Vol. 52(Issue: 2),
 pp. 279–319,
 DOI: 10.1016/j.rcl.2013.11.008,
 PMID: 24582341,</ref> Myelin is a fatty white substance that acts as an electrical insulator and coats axons in order to speed up impulses (i.e., action potentials) traveling down the axon. Thus, the natural result of a loss of this substance is decreased efficiency in impulse propagation. As myelin is produced by oligodendrocytes (a type of glial cell) in the central nervous system, an easy place to look for the cause is a mutation or malfunctioning of these cells and in other glial cells.

Genetic influence

Autorecessive Inheritance Pattern

Leukodystrophy is most often an inherited disease that is usually the result of an autosomal recessive inheritance pattern, although dominant inheritance patterns are not unheard of, as in the case of adult-onset leukodystrophy.<ref name="Autosomal Dominant Leukodystrophy">,

 Adult-Onset Autosomal Dominant Leukodystrophy: Linking Nuclear Envelope to Myelin, 
 The Journal of Neuroscience, 
 
 Vol. 31(Issue: 4),
 pp. 1163–1166,
 DOI: 10.1523/jneurosci.5994-10.2011,
 PMID: 21273400,
 PMC: 3078713,</ref> This means that the affected allele is carried on an autosomal, or non-sex, chromosome and is masked by the dominant, unaffected phenotype. In other words, for an individual to inherit the leukodystrophy phenotype, he or she must carry two of the recessive, mutant alleles. Krabbe disease and metachromatic leukodystrophy (MLD) are two of such type. MLD is found on human chromosome 22 at position q13.31.<ref name="Metachromatic - Chromosome #">, 
 Metachromatic leucodystrophy (MLD) in a patient with a constitutional ring chromosome 22, 
 Journal of Medical Genetics, 
 
 Vol. 32(Issue: 10),
 pp. 787–91,
 DOI: 10.1136/jmg.32.10.787,
 PMID: 8558556,
 PMC: 1051701,</ref> Another type of inherited leukodystrophy is X-linked adrenoleukodystrophy (X-ALD). As its name implies, this type of leukodystrophy is the result of a mutation found on the X-chromosome. It is also carried in a recessive pattern. The X chromosome is a sex chromosome, and since women have two “chances” of acquiring a normal X chromosome (one maternal, one paternal), and males only one (one maternal), this disease is more likely to be seen in men than in women. The mutation resulting in adult-onset leukodystrophy is mapped at 5q23.<ref name="Autosomal Dominant Leukodystrophy" />

Pathophysiology

Although there are nearly forty different types of leukodystrophies, many are lacking in formal and comprehensive research. Most of the research so far has been done on five types: (1) metachromatic leukodystrophy (MLD), (2) Krabbe disease, (3) X-Linked adrenoleukodystrophy (ALD), (4) Canavan disease, and (5) Alexander disease. Each type of leukodystrophy has a unique pathophysiology, but all five of these in some way affect a subset of glial cells, therefore disrupting myelin production and maintenance, and usually involve a mutation involving genes that code for enzymes necessary for the catabolism of very long chain fatty acids (VLCFAs) that are toxic to the myelin-producing cells of the central nervous system.<ref name=VFCLAs>,

 Metabolism of Very Long-Chain Fatty Acids: Genes and Pathophysiology, 
 Biomolecules & Therapeutics, 
 
 Vol. 22(Issue: 2),
 pp. 83–92,
 DOI: 10.4062/biomolther.2014.017,
 PMID: 24753812,
 PMC: 3975470,</ref>

Metachromatic leukodystrophy

Main article: Metachromatic leukodystrophy

Metachromatic leukodystrophy is the result of genetic defects in the enzymes associated with the cellular compartment the lysosome. MLD is one of two leukodystophies that are also a lysosomal storage disorder. MLD is inherited in an autosomal recessive way and is the result of mutations in three different ARSA alleles that encode the enzyme arylsulfatase A (ASA or sometimes ARSA), also called sulfatide sulfatase.<ref name="Metachromatic - ABSTRACT only">,

 Metachromatic leucodystrophy. Clinical, biological, and therapeutic aspects, 
 Annales de Biologie Clinique, 
 
 Vol. 68(Issue: 4),
 pp. 385–91,
 DOI: 10.1684/abc.2010.0448,
 PMID: 20650733,</ref> ASA is responsible for the breakdown of sulfatides, sphingolipids present in neuronal membranes as well as in myelin. When there is a mutation in the gene that encodes ASA, the result is it decreases production, which subsequently leads to diminished degradation of sulfatides, thus causing them to accumulate.<ref name="Metachromatic - ABSTRACT only" /> This accumulation of sulfatides is poisonous to oligodendrocytes, the myelin-producing cells of the CNS, effectively leading to a disturbance in myelin structure followed by demyelination. The pattern of inheritance of the three different alleles affects what type of MLD a person develops. Two null alleles are responsible for the infantile version, and do not allow for any production of ASA. A heterozygous individual (one null allele, one non-null allele) develops the juvenile form and sees some production of ASA, while an individual with two non-null alleles (but still mutated) develops the adult form.<ref name="Metachromatic Leuko 2. - ABSTRACT ONLY">, 
 Metachromatic Leukodystrophy - An Update, 
 Neuropediatrics, 
 
 Vol. 41(Issue: 1),
 pp. 1–6,
 DOI: 10.1055/s-0030-1253412,
 PMID: 20571983,</ref>

Krabbe disease

Globoid cell leukodystrophy PAS - Multinucleated macrophages ("globoid cells") and loss of myelinated fibers in a case of Krabbe's leukodystrophy

Main article: Krabbe disease

Like MLD, Krabbe disease is another type of leukodystrophy with autosomal recessive inheritance that is the result of a lysosomal storage disorder. It is due to a deletion in exon 16 of the GALC gene that causes a frameshift mutation leading to a premature stop codon. The GALC gene, found on chromosome 14 at position 31 (14q31), codes for the enzyme beta-galactocerebrosidase (GALC).<ref name="Szymanska - Krabbe">,

 Diagnostic difficulties in Krabbe disesase: a report of two cases and review of literature, 
 Folia Neuropathol, 
 
 Vol. 50(Issue: 4),
 pp. 346–356,
 DOI: 10.5114/fn.2012.32364,
 PMID: 23319190,</ref> GALC is a lysosomal enzyme responsible for the catabolism of galactolipids, especially psychosine, that are heavily distributed throughout the brain. A deficiency in GALC thus causes a buildup of these fatty acids known as globoid macrophages that destroy oligodendrocytes, thereby inhibiting myelin formation.<ref name="Globoid cells and arylsufatase - ABSTRACT ONLY">, 
  
 Lysosomal leukodystrophies - Krabbe disease and metachromatic leukodystrophy, 
  
  
  
  
 Volume: 113, 
 ISBN 9780444595652, 
 DOI: 10.1016/B978-0-444-59565-2.00029-0, 
  
  
 Pages: 1611–1618,</ref>

Because of the presence of globoid cells clustered near white matter, Krabbe disease often goes by the name globoid cell leukodystrophy. Furthermore, new research has shown that Krabbe disease and globoid cell leukodystrophy may be distinct disease entities due to the secretion of inflammatory mediators by natural killer cells in some cases.<ref name="Natural Killer Cells">,

 On the Role of Natural Killer Cells in Neurodegenerative Diseases, 
 Toxins (Basel), 
 
 Vol. 5(Issue: 2),
 pp. 363–375,
 DOI: 10.3390/toxins5020363,
 PMID: 23430541,
 PMC: 3640540,</ref> This research has shown that Natural Killer cells have receptors (TDAG8) for certain glycosphingolipids that build up in an individual with leukodystrophy, again due to insufficient GALC levels, and when bound, target the Natural Killer cells for destruction thereby preventing their cytotoxic effects. These sphingolipids have been identified as galactosyl sphingosine and glycosyl sphingosine and are not present in unaffected individuals.<ref name="Natural Killer Cells" />

Canavan disease

Main article: Canavan disease

Canavan disease is a lesser-studied type of leukodystrophy that, like MLD and Krabbe disease, is also passed on in an autosomal recessive inheritance pattern. It is due to a mutation in the ASPA gene that encodes aspartoacylase, an enzyme needed to metabolize N-acetyl-L-aspartate (NAA). The mutation causes a deficiency of aspartoacyclase. NAA is involved in the formation of lipids, and if it is not broken down by aspartoacylase, excess levels of it build up causing demyelination.<ref name="Canavan Disease - ULF">

Canavan Disease(link). United Leukodystrophy Foundation. United Leukodystrophy Foundation, Inc..

</ref>

X-linked adrenoleukodystrophy

Main article: Adrenoleukodystrophy

In X-linked adrenoleukodystrophy (X-ALD), a mutation occurs in the peroxisomal ATP-binding cassette (ABC transporter). This leads to cerebral inflammatory demyelination caused by the myelin destabilization that occurs in these patients.<ref name=berger>,

 Pathophysiology of X-Linked Adrenoleukodystrophy, 
 Biochimie, 
 
 Vol. 98,
 pp. 135–142,
 DOI: 10.1016/j.biochi.2013.11.023,
 PMID: 24316281,
 PMC: 3988840,</ref> The inflammatory demyelination begins in the corpus callosum and it slowly progresses outwards towards both hemispheres. In X-ALD patients, abnormally high levels of very long chain fatty acid (VLCFA) accumulate in various body tissues and fluids. This increased concentration then incorporates into various complex lipids where they are not normally found.<ref name=berger /> This has been found to be directly involved in the cerebral inflammation. The accumulated and embedded VLCFA in the complex lipids could lead to the destabilization of myelin sheath and eventually to demyelination.

Alexander disease

Main article: Alexander disease

Alexander disease is unique from the leukodystrophies mentioned above in that it is the result of spontaneous mutation, that is it is not inherited. This means that the mutation found in the affected individual is not found in either of his or her parents. It is due to the accumulation of Glial fibrillary acidic protein (GFAP) as the result of a mutation in the GFAP gene; which, rather than being found in association with lysosomes or peroxisomes, is an intermediate filament linked to the nuclear envelope.<ref name="Alexander's Disease">,

 Alexander's disease: reassessment of a neonatal form, 
 Child's Nervous System, 
 
 Vol. 28(Issue: 12),
 pp. 2029–2031,
 DOI: 10.1007/s00381-012-1868-8,
 PMID: 22890470,</ref> Intermediate filaments are proteins responsible for the makeup of the cellular cytoskeleton, and thus this type of mutation is involved in malfunctioning structural development of the cells. In fact, cytoskeletal and transporter molecule defects have been observed in the astrocytes (type of glial cell) of affected individuals. These astrocytes have an unhealthily large amount of GFAP that affects astrocyte formation and function.<ref name=GFAP>, 
 Glial fibrillary acidic protein (GFAP) and the astrocyte intermediate filament system in diseases of the central nervous system, 
 Current Opinion in Cell Biology, 
 
 Vol. 32(Issue: Cell Architecture),
 pp. 121–130,
 DOI: 10.1016/j.ceb.2015.02.004,
 PMID: 25726916,</ref>

Diagnosis

The degeneration of white matter, which shows the degeneration of myelin, can be seen in a basic MRI and used to diagnose leukodystrophies of all types. T-1 and T-2 weighted FLAIR images are the most useful. FLAIR stands for fluid-attenuated inversion recovery.<ref name="Diagnosis - MRI">,

 Childhood leukodystrophies: a clinical perspective, 
 Expert Review of Neurotherapeutics, 
 
 Vol. 11(Issue: 10),
 pp. 1485–1496,
 DOI: 10.1586/ern.11.135,
 PMID: 21955203,
 
 
 Full text,</ref> Electrophysiological and other kinds of laboratory testing can also be done. In particular, nerve conduction velocity is looked at to distinguish between leukodystrophy and other demyelinating diseases, as well as to distinguish between individual leukodystrophies. For example, individuals with X-ALD have normal conduction velocities, while those with Krabbe disease or metachromatic leukodystrophy have abnormalities in their conduction velocities.<ref name="Diagnosis - MRI" /> Next generation multigene sequencing panels for undifferentiated leukodystrophy can now be offered for rapid molecular diagnosis after appropriate genetic counselling.

Types

Specific types of leukodystrophies include the following with their respective ICD-10 codes when available:

• (E71.3) Adrenomyeloneuropathy
• (E75.2) Alexander disease
• (E75.5) Cerebrotendineous xanthomatosis
• Hereditary CNS demyelinating disease
  • (E75.2) Krabbe disease
  • (E75.2) Metachromatic leukodystrophy
  • (E75.2) Pelizaeus–Merzbacher disease
  • (E75.2) Canavan disease
  • (E75.2) Hypomyelinating leukodystrophy type 7 (4H syndrome)
  • (G93.49) Leukoencephalopathy with vanishing white matter
  • (E71.3) Adrenoleukodystrophy
• (G60.1) Refsum disease

Treatment

With many different types of leukodystrophies and causes, treatment therapies vary for each type. Many studies and clinical trials are in progress to find treatment and therapies for each of the different leukodystrophies. Stem cell transplants and gene therapy appear to be the most promising in treating all leukodystrophies providing it is done as early as possible. For hypomyelinating leukodystrophies, therapeutic research into cell-based therapies appears promising. Oligodendrocyte precursor cells and neural stem cells have been transplanted successfully and have shown to be healthy a year later. Fractional anisotropy and radial diffusivity maps showed possible myelination in the region of the transplant.<ref name=Pouwels>,

 Hypomyelinating Leukodystrophies: Translational Research Progress and Prospects, 
 Ann. Neurol., 
 
 Vol. 76(Issue: 1),
 pp. 5–19,
 DOI: 10.1002/ana.24194,
 PMID: 24916848,
 
 
 Full text,</ref> Induced pluripotent stem cells, oligodendrocyte precursor cells, gene correction, and transplantation to promote the maturation, survival, and myelination of oligodendrocytes seem to be the primary routes for possible treatments.<ref name="Pouwels"/>

For three types of leukodystrophies (X-linked adrenoleukodystrophy (X-ALD), metachromatic leukodystrophy (MLD) and Krabbe Disease (globoid cell leukodystrophy - GLD), gene therapy using autologous hematopoietic stem cells to transfer the disease gene with lentiviral vectors have shown to be successful and are currently being used in clinical trials for X-ALD and MLD.<ref name=Biffi>,

 Gene therapy for leukodystrophies, 
 Human Molecular Genetics, 
 2011,
 Vol. 20(Issue: R1),
 pp. R42–R53,
 DOI: 10.1093/hmg/ddr142,
 PMID: 21459776,</ref> The progression of X-ALD has shown to be disrupted with hematopoietic stem cell gene therapy but the exact reason why demyelination stops and the amount of stem cells needed is unclear.<ref name=Biffi /> While there is an accumulation of very long chain fatty acids in the brain, it does not seem to be the reason behind the disease as gene therapy does not correct it.<ref name=Biffi />

Adeno-associated vectors have also been used in intracerebral injections to treat MLD. In some patients with MLD, their IQ increased, nerve conduction improved, their MRIs appeared stable, and had normal enzyme levels.<ref name=Biffi /> Although the greater majority of patients seem to improve after the transplant, some do not respond well to treatment, which may cause devastating outcomes. For those leukodystrophies that result from a deficiency of lysozyme enzymes, such as Krabbe disease, enzyme replacement therapy seems hopeful. However, enzyme delivery proves difficult, because the blood-brain barrier severely limits what can pass into the central nervous system.<ref name=Biffi /> Due to this obstacle, most research and clinical trials are turning to allogeneic hematopoietic stem cell transplantation.

Epidemiology

File:2928 X-linked Recessive Inheritance-new.jpg

X-linked Recessive Inheritance

Currently, no research has shown a higher prevalence of most leukodsytrophy types in any one place around the world. There is, however, a higher prevalence of the Canavan disease in the Jewish population. 1 in 40 individuals of Ashkenazi Jewish descent are carriers of Canavan disease.<ref name="Ashkenazi Jews/Canavan - ABSTRACT ONLY">,

 Canavan disease: Carrier-frequency determination in the Ashkenazi Jewish population and development of a novel molecular diagnostic assay, 
 American Journal of Medical Genetics, 
 
 Vol. 124A(Issue: 2),
 pp. 142–7,
 DOI: 10.1002/ajmg.a.20334,
 PMID: 14699612,</ref> This estimates to roughly 2.5%. Additionally, due to an autosomal recessive inheritance patterns, there is no significant difference found between affected males and affected females for most types of leukodystrophy including, but not limited to, metachromatic leukodystrophy, Krabbe disease, Canavan disease, and Alexander disease. The one exception to this is any type of leukodystrophy carried on a sex chromosome, such as X-linked adrenoleukodystrophy, which is carried on the X-chromosome. Because of the inheritance pattern of X-linked diseases, males are more often affected by this type of leukodystrophy, although female carriers are often symptomatic, though not as severely so as males.<ref name="Genetics - Epidemiology - ABSTRACT">, 
 X-linked adrenoleukodystrophy in a female proband: clinical presentation, biological diagnosis and family consequences, 
 Archives de Pédiatrie, 
 
 Vol. 12(Issue: 8),
 pp. 1237–40,
 DOI: 10.1016/j.arcped.2005.03.050,
 PMID: 15878823,</ref> To date, there have been no found cases of a leukodystrophy carried on the Y chromosome.

Current research

MLD Foundation provides updates on MLD research, including (as of 2019) two active clinical trials evaluating gene therapy and enzyme replacement therapy, and various lines of basic research. They are also active in newborn screening.

The Global Leukodystrophy Initiative was formed in 2013 to bring together clinicians, researchers and advocacy groups to focus and improve both clinical care and research.

In addition, many research groups are studying the cellular processes of myelination, which may provide insights into leukodystrophy. Researchers in New York have successfully cured leukodystrophy in mice, using skin cells to repair damaged myelin sheaths. Researchers hypothesize that this treatment may possibly be used in curing human multiple sclerosis.<ref>

Human Skin Cells Used to Create Stem Cells, Treat Brain Disease in Mice(link). {{{website}}}. DailyTech. 8 February 2013.

</ref>

Society

Cure MLD is a global network of patient advocates and nonprofits dedicated to helping families impacted by metachromatic leukodystrophy (MLD). Cure MLD is here to connect families with resources, information, support, and others dealing with MLD. Cure MLD provides travel grants, care packages, emotional support, educational materials, and opportunities to interact with families and patients. Support for the site comes from Chloe's Fight, Love for Loie and The Hammond Family, The Sullivan Family and Friends, Gavin Flying for a Cure, The Calliope Joy Foundation/Cal's Cupcakes, Fundacion Lautaro te Necesita (Argentina), Leukodystrophy Resource and Research Organization (Australia), Bethany's Hope (Canada), and MLD families around the globe. "We are united in our mission to Cure MLD"

MLD Foundation was co-founded by Dean and Teryn Suhr in 2001 after the diagnosis in 1995 of two of their daughters with MLD. MLD Foundation serves families and works with researchers, clinicians, regulators, payors, and policy-makers around the world on MLD, leukodystrophy, lysosomal, and rare disease issues. The foundation's mission is "We C.A.R.E.™ ... Compassion for families, increasing Awareness, influencing & funding Research, and promoting Education for metachromatic leukodystrophy, a very rare terminal genetic neuro-metabolic disease where over half the cases affect infants."

The World Leukodystrophy Alliance is increasing awareness and working to improve quality of care for the leukodystrophies.

Jill Kelly and her husband, NFL quarterback Jim Kelly, founded Hunter's Hope after their son Hunter (1997-2005) was diagnosed with infantile Krabbe leukodystrophy.<ref name="hunters">Staff report (October 25, 2012). Game show winners donate portion to Hunter’s Hope. Buffalo News</ref> Matthew and Michael Clark of Hull, UK were sufferers, unfortunately both succumbing to the illness and dying in 2013 & 2016 respectively. Their story was the subject of the Channel 4 documentary The Curious Case of the Clark Brothers.<ref name="Channel4">

The Curious Case of the Clark Brothers(link). {{{website}}}.

</ref>

Augusto and Michaela Odone founded The Myelin Project after their son, Lorenzo was diagnosed with Adrenoleukodystrophy (ALD).

The 1992 film, Lorenzo's Oil is a true story about a boy suffering from Adrenoleukodystrophy (ALD).

See also

• Leukoencephalopathy