Bupropion/zonisamide

Bupropion/Zonisamide

Chemical structures of Bupropion and Zonisamide

Bupropion/zonisamide is a combination of two pharmacological agents, bupropion and zonisamide, which are used in the treatment of various conditions, including depression, obesity, and epilepsy. This combination leverages the unique mechanisms of action of each drug to provide therapeutic benefits.

Bupropion

Bupropion is an atypical antidepressant that primarily acts as a norepinephrine-dopamine reuptake inhibitor (NDRI). It is commonly used to treat major depressive disorder and seasonal affective disorder. Bupropion is also prescribed as an aid to smoking cessation under the brand name Zyban.

Mechanism of Action

Bupropion works by inhibiting the reuptake of norepinephrine and dopamine, two neurotransmitters involved in mood regulation. This action increases the concentration of these neurotransmitters in the synaptic cleft, enhancing neurotransmission and improving mood.

Side Effects

Common side effects of bupropion include insomnia, dry mouth, and headache. It is important to note that bupropion lowers the seizure threshold, which can increase the risk of seizures in susceptible individuals.

Zonisamide

Zonisamide is an anticonvulsant medication used primarily in the treatment of epilepsy. It is also used off-label for weight loss and as an adjunct in the treatment of bipolar disorder.

Mechanism of Action

Zonisamide works by blocking sodium channels and reducing calcium influx, which stabilizes neuronal membranes and suppresses abnormal electrical activity in the brain. It also has a weak inhibitory effect on carbonic anhydrase, which may contribute to its anticonvulsant properties.

Side Effects

Common side effects of zonisamide include drowsiness, dizziness, and anorexia. It can also cause metabolic acidosis and kidney stones in some patients.

Combination Use

The combination of bupropion and zonisamide is used to exploit the complementary mechanisms of action of both drugs. Bupropion's effects on mood and energy levels can be enhanced by zonisamide's stabilizing effects on neuronal activity. This combination is sometimes used in the management of obesity due to the appetite-suppressing effects of both drugs.

Related Pages

• Antidepressant
• Anticonvulsant
• Norepinephrine-dopamine reuptake inhibitor
• Epilepsy
• Obesity