ADME
ADME
ADME is an acronym in pharmacokinetics and pharmacology for Absorption, Distribution, Metabolism, and Excretion. These are the four criteria that influence the drug levels and kinetics of drug exposure to the tissues and hence influence the performance and pharmacological activity of the compound as a drug.
Absorption
Absorption is the process by which a drug passes into the bloodstream. The rate and extent of absorption are influenced by the route of administration, the drug's formulation, and the patient's physiological state.
Distribution
Distribution refers to the dispersion or dissemination of substances throughout the fluids and tissues of the body. The distribution of a drug between tissues is dependent on vascular permeability, regional blood flow, cardiac output and perfusion rate of the tissue and the ability of the drug to bind tissue and plasma proteins and its lipid solubility.
Metabolism
Metabolism is the process by which the body breaks down and converts medication into active chemical substances. It is also referred to as biotransformation. The liver is the primary site for metabolism. However, pulmonary, renal, and skin metabolism also occurs.
Excretion
Excretion is the process by which the drugs are eliminated from the body. The kidney is the main organ for the excretion of drugs and their metabolites. Other routes of excretion include bile, saliva, sweat, and breast milk.
See Also
External links
- Medical encyclopedia article on ADME
- Wikipedia's article - ADME
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