Angiotensin II receptor blocker
Angiotensin II receptor blocker
Angiotensin II receptor blockers (ARBs), also known as angiotensin receptor antagonists, are a group of pharmaceuticals that modulate the renin-angiotensin system. Their main uses are in the treatment of hypertension (high blood pressure), diabetic nephropathy (kidney damage due to diabetes) and congestive heart failure.
Pronunciation
Angiotensin: /ˌændʒioʊˈtɛnsɪn/ Receptor: /rɪˈsɛptər/ Blocker: /ˈblɒkər/
Etymology
The term "Angiotensin" comes from the words "angio-" meaning vessel and "-tensin" meaning tension, referring to its function in vasoconstriction and the increase of blood pressure. The term "receptor blocker" refers to the drug's function of blocking the receptors that angiotensin II binds to.
Mechanism of Action
ARBs work by blocking the action of angiotensin II, a hormone that causes blood vessels to constrict (narrow). By blocking the receptors that angiotensin II binds to, ARBs allow blood vessels to relax and widen, which lowers blood pressure.
Related Terms
- Angiotensin
- Angiotensin II
- Renin-angiotensin system
- Hypertension
- Diabetic nephropathy
- Congestive heart failure
See Also
References
External links
- Medical encyclopedia article on Angiotensin II receptor blocker
- Wikipedia's article - Angiotensin II receptor blocker
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