Omapatrilat

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Omapatrilat

Omapatrilat (pronounced oh-ma-PAT-ri-lat) is a type of vasopeptidase inhibitor used in the treatment of hypertension and heart failure. It is a dual inhibitor of the enzymes neprilysin (also known as neutral endopeptidase) and angiotensin converting enzyme (ACE), which are involved in the regulation of blood pressure and fluid balance in the body.

Etymology

The name "Omapatrilat" is derived from the names of the two enzymes it inhibits: "Oma" from neprilysin (formerly known as Omega-mammalian metalloprotease), and "patrilat" from pathway rinolysin lattice, a reference to its action on the renin-angiotensin system.

Usage

Omapatrilat is used in the treatment of conditions such as hypertension and heart failure, where it works by inhibiting the enzymes neprilysin and ACE. This results in a decrease in blood pressure and an improvement in heart function.

Related Terms

  • Vasopeptidase inhibitor: A class of drugs that inhibit the enzymes neprilysin and ACE, thereby reducing blood pressure and improving heart function.
  • Hypertension: A medical condition characterized by high blood pressure.
  • Heart failure: A condition in which the heart is unable to pump enough blood to meet the body's needs.
  • Neprilysin: An enzyme that breaks down certain peptides in the body, including some that regulate blood pressure and fluid balance.
  • Angiotensin converting enzyme (ACE): An enzyme that converts angiotensin I to angiotensin II, a potent vasoconstrictor.

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