Delapril

An overview of the antihypertensive drug Delapril

Delapril
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Delapril is a medication used primarily in the treatment of hypertension (high blood pressure). It belongs to the class of drugs known as angiotensin-converting enzyme inhibitors (ACE inhibitors), which work by relaxing blood vessels and reducing the workload on the heart.

Mechanism of action

Delapril functions by inhibiting the angiotensin-converting enzyme (ACE), which is responsible for the conversion of angiotensin I to angiotensin II. Angiotensin II is a potent vasoconstrictor, meaning it narrows blood vessels and increases blood pressure. By blocking this conversion, Delapril helps to lower blood pressure and improve blood flow.

Pharmacokinetics

Delapril is administered orally and is absorbed through the gastrointestinal tract. It is a prodrug, meaning it is metabolized into its active form, delaprilat, in the liver. The drug is then excreted primarily through the kidneys.

Clinical uses

Delapril is used to manage hypertension and may be prescribed alone or in combination with other antihypertensive agents. It is also used in the treatment of heart failure and to improve survival after a myocardial infarction (heart attack).

Side effects

Common side effects of Delapril include cough, dizziness, and fatigue. Like other ACE inhibitors, it can cause hyperkalemia (elevated potassium levels) and angioedema (swelling of the deeper layers of the skin). Patients are advised to report any signs of swelling or difficulty breathing to their healthcare provider immediately.

Contraindications

Delapril is contraindicated in patients with a history of angioedema related to previous ACE inhibitor therapy and in those with renal artery stenosis. It should not be used during pregnancy due to the risk of fetal harm.

Related pages

• Hypertension
• ACE inhibitors
• Heart failure
• Myocardial infarction

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  Delapril