Enalaprilat

Enalaprilat

Chemical structure of Enalaprilat

Enalaprilat is an angiotensin-converting enzyme inhibitor (ACE inhibitor) used primarily in the treatment of hypertension and congestive heart failure. It is the active metabolite of the prodrug enalapril. Enalaprilat is administered intravenously, which makes it suitable for patients who cannot take oral medications.

Pharmacology

Enalaprilat works by inhibiting the angiotensin-converting enzyme, which is responsible for the conversion of angiotensin I to angiotensin II. Angiotensin II is a potent vasoconstrictor, and its inhibition leads to vasodilation, reduced blood pressure, and decreased workload on the heart. This mechanism is beneficial in managing conditions such as hypertension and heart failure.

Clinical Use

Enalaprilat is used in situations where rapid blood pressure control is necessary, such as in hypertensive emergencies. It is also used in patients who are unable to take oral medications due to conditions like vomiting or gastrointestinal obstruction.

Administration

Enalaprilat is administered intravenously, typically in a hospital setting. The dosage and frequency depend on the patient's condition and response to the medication. It is important to monitor blood pressure and renal function during treatment.

Side Effects

Common side effects of enalaprilat include hypotension, dizziness, and renal impairment. Less common but serious side effects can include angioedema and hyperkalemia. Patients with a history of angioedema related to previous ACE inhibitor use should not receive enalaprilat.

Contraindications

Enalaprilat is contraindicated in patients with a history of angioedema related to previous ACE inhibitor therapy, and in patients with bilateral renal artery stenosis. It should be used with caution in patients with impaired renal function.

Related Pages

• Enalapril
• Angiotensin-converting enzyme inhibitor
• Hypertension
• Congestive heart failure