Alacepril

{{Drugbox | verifiedfields = changed | verifiedrevid = 477002679 | IUPAC_name = (2S)-1-[(2S)-2-[[2-[[2-(acetylsulfanyl)acetyl]amino]acetyl]amino]-3-phenylpropanoyl]pyrrolidine-2-carboxylic acid | image = Alacepril.svg | image2 = Alacepril_synthesis.svg | width2 = 250 }}

Alacepril is a medication that belongs to the class of angiotensin-converting enzyme inhibitors (ACE inhibitors). It is primarily used in the management of hypertension and heart failure.

Mechanism of action

Alacepril works by inhibiting the angiotensin-converting enzyme (ACE), which is responsible for the conversion of angiotensin I to angiotensin II. Angiotensin II is a potent vasoconstrictor that increases blood pressure by causing blood vessels to constrict. By inhibiting this enzyme, alacepril reduces the formation of angiotensin II, leading to vasodilation and a subsequent decrease in blood pressure.

Pharmacokinetics

Alacepril is administered orally and is absorbed in the gastrointestinal tract. It is a prodrug, which means it is converted into its active form, enalaprilat, in the body. The conversion occurs primarily in the liver. The active metabolite enalaprilat is responsible for the therapeutic effects of alacepril.

Clinical uses

Alacepril is used in the treatment of:

• Hypertension: By lowering blood pressure, alacepril helps reduce the risk of stroke, myocardial infarction, and kidney failure.
• Heart failure: It helps improve symptoms and reduce the risk of hospitalization in patients with heart failure.

Side effects

Common side effects of alacepril include:

• Cough
• Hyperkalemia (elevated potassium levels)
• Hypotension (low blood pressure)
• Dizziness

Less common but serious side effects include:

• Angioedema
• Renal impairment

Contraindications

Alacepril is contraindicated in patients with:

• A history of angioedema related to previous treatment with an ACE inhibitor
• Pregnancy, due to the risk of fetal harm

Related pages

• ACE inhibitor
• Hypertension
• Heart failure
• Angiotensin II

Gallery

• 
  Chemical structure of Alacepril
• 
  Synthesis of Alacepril

• 
  Alacepril
• 
  Alacepril synthesis