Zofenopril
Zofenopril is an angiotensin-converting enzyme inhibitor (ACE inhibitor) used in the treatment of hypertension and ischemic heart disease. It is a prodrug, converted in the liver to the active form, zofenoprilat.
Pharmacology
Zofenopril is a sulfhydryl group-containing ACE inhibitor. It is a prodrug and is converted to the active metabolite zofenoprilat in the liver. The conversion is not affected by the presence of food in the stomach. Zofenoprilat inhibits the angiotensin-converting enzyme, which is involved in the conversion of angiotensin I to angiotensin II. This results in a decrease in angiotensin II, leading to a decrease in aldosterone secretion, and an increase in serum renin activity.
Clinical use
Zofenopril is used in the treatment of hypertension and ischemic heart disease. In hypertension, it is used as monotherapy or in combination with other antihypertensive agents. In ischemic heart disease, it is used in the treatment of myocardial infarction and in the prevention of heart failure.
Side effects
The most common side effects of zofenopril are cough, dizziness, and rash. Other side effects include hyperkalemia, hypotension, and renal impairment. Rarely, it can cause angioedema.
Contraindications
Zofenopril is contraindicated in patients with a history of angioedema related to previous treatment with an ACE inhibitor. It is also contraindicated in patients with bilateral renal artery stenosis, hypersensitivity to zofenopril, and in patients with a history of idiopathic angioedema.
See also
Cardiovascular disease A-Z
Most common cardiac diseases
- Cardiac arrhythmia
- Cardiogenetic disorders
- Cardiomegaly
- Cardiomyopathy
- Cardiopulmonary resuscitation
- Chronic rheumatic heart diseases
- Congenital heart defects
- Heart neoplasia
- Ischemic heart diseases
- Pericardial disorders
- Syndromes affecting the heart
- Valvular heart disease
A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z
A
- Accelerated idioventricular rhythm
- Acute decompensated heart failure
- Arteriosclerotic heart disease
- Athletic heart syndrome
- Atrial flutter
- Atrioventricular fistula
- Cardiovascular disease in Australia
- Autoimmune heart disease
B
C
- Ebb Cade
- Cardiac allograft vasculopathy
- Cardiac amyloidosis
- Cardiac asthma
- Cardiac tamponade
- Cardiogenic shock
- Cardiogeriatrics
- Cardiorenal syndrome
- Cardiotoxicity
- Carditis
- Coronary artery aneurysm
- Coronary artery anomaly
- Coronary artery disease
- Spontaneous coronary artery dissection
- Coronary artery ectasia
- Coronary occlusion
- Coronary steal
- Coronary thrombosis
- Coronary vasospasm
- Cœur en sabot
- Coxsackievirus-induced cardiomyopathy
D
E
H
- Heart attack
- Heart failure
- Heart failure with preserved ejection fraction
- Heart to Heart (1949 film)
- High-output heart failure
- Hyperdynamic precordium
A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z
I
- Idiopathic giant-cell myocarditis
- Interventricular dyssynchrony
- Intraventricular dyssynchrony
- Isolated atrial amyloidosis
K
L
M
- Mydicar
- Myocardial bridge
- Myocardial disarray
- Myocardial rupture
- Myocardial scarring
- Myocardial stunning
- Myocarditis
N
O
P
- Papillary fibroelastoma
- Pathophysiology of heart failure
- Postpericardiotomy syndrome
- Pulmonary vein stenosis
R
S
- Saturated fat and cardiovascular disease
- SCAR-Fc
- Shone's syndrome
- Strain pattern
- Subacute bacterial endocarditis
- Sudden cardiac death of athletes
A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z
T
V
W
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