RNA splicing

RNA Splicing

RNA splicing is a modification process that occurs after transcription, in which introns are removed from pre-mRNA and exons are joined together. This process is crucial for gene expression in eukaryotes.

Pronunciation

RNA splicing is pronounced as /ɑːrɛnˈeɪ ˈsplʌɪsɪŋ/.

Etymology

The term "RNA splicing" is derived from the English words "RNA" (Ribonucleic Acid) and "splicing" (joining or connecting). The process was first identified in the late 1970s.

Process

RNA splicing begins with the assembly of helper proteins at the intron/exon borders. These proteins form a spliceosome, a large RNA-protein molecular complex upon the pre-mRNA molecule. The spliceosome helps in the precise cutting and rejoining of the RNA molecule to release the introns and join the exons together.

Types of RNA Splicing

There are two main types of RNA splicing: Alternative Splicing and Self-Splicing.

Alternative Splicing

In alternative splicing, different combinations of exons are joined together and introns are removed, resulting in different mRNA molecules. This process allows a single gene to produce multiple proteins.

Self-Splicing

In self-splicing, the introns are capable of removing themselves and joining the exons together without the help of the spliceosome.

Related Terms

• Exon
• Intron
• Spliceosome
• mRNA
• Gene Expression
• Transcription

External links

• Medical encyclopedia article on RNA splicing
• Wikipedia's article - RNA splicing

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