Interleukin 17: Difference between revisions

Latest revision as of 04:06, 13 February 2025

Interleukin 17[edit]

Interleukin 17 (IL-17) is a pro-inflammatory cytokine that plays a crucial role in the immune system. It is part of a family of cytokines known as the IL-17 family, which includes six members: IL-17A, IL-17B, IL-17C, IL-17D, IL-17E (also known as IL-25), and IL-17F. These cytokines are produced by a variety of cells, including T helper 17 cells (Th17), a subset of CD4+ T cells.

Function[edit]

Interleukin 17 is primarily involved in the regulation of immune responses, particularly in the defense against extracellular bacteria and fungi. It stimulates the production of other pro-inflammatory cytokines, such as tumor necrosis factor (TNF) and interleukin 6 (IL-6), and promotes the recruitment of neutrophils to sites of infection.

IL-17 Family[edit]

The IL-17 family consists of six cytokines, each with distinct roles in immune regulation:

IL-17A: The most studied member, involved in autoimmune diseases and chronic inflammatory conditions.
IL-17B: Less understood, but implicated in inflammatory responses.
IL-17C: Plays a role in epithelial cell responses to infection.
IL-17D: Involved in the regulation of innate immunity.
IL-17E (IL-25): Promotes Th2 cell responses and is involved in allergic reactions.
IL-17F: Similar to IL-17A, involved in mucosal immunity.

Clinical Significance[edit]

IL-17 has been implicated in a variety of autoimmune diseases, including rheumatoid arthritis, psoriasis, and multiple sclerosis. It is also associated with chronic inflammatory conditions such as inflammatory bowel disease (IBD). Targeting IL-17 with specific monoclonal antibodies has become a therapeutic strategy in treating these diseases.

Related Pages[edit]

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-'''Interleukin 17''' (IL-17), also known as '''IL-17A''', is a pro-inflammatory [[cytokine]] that plays a crucial role in host defense mechanisms and inflammatory diseases. It is produced by a subset of [[T cells]] known as Th17 cells, which are part of the [[adaptive immune system]].
+== Interleukin 17 ==
+[[File:IL17F_1JPY.png|thumb|right|Structure of Interleukin 17F]]
+'''Interleukin 17''' (IL-17) is a pro-inflammatory [[cytokine]] that plays a crucial role in the immune system. It is part of a family of cytokines known as the IL-17 family, which includes six members: IL-17A, IL-17B, IL-17C, IL-17D, IL-17E (also known as IL-25), and IL-17F. These cytokines are produced by a variety of cells, including [[T helper 17 cells]] (Th17), a subset of [[CD4+ T cells]].
 == Function ==
-IL-17 has a wide range of functions in the immune system. It is primarily involved in the defense against extracellular bacteria and fungi by inducing the production of other cytokines, chemokines, and antimicrobial peptides. This leads to the recruitment and activation of [[neutrophils]], which are essential for the clearance of these pathogens.
+Interleukin 17 is primarily involved in the regulation of [[immune response]]s, particularly in the defense against extracellular [[bacteria]] and [[fungi]]. It stimulates the production of other pro-inflammatory cytokines, such as [[tumor necrosis factor]] (TNF) and [[interleukin 6]] (IL-6), and promotes the recruitment of [[neutrophils]] to sites of infection.
+== IL-17 Family ==
-In addition to its role in host defense, IL-17 is also implicated in the pathogenesis of various inflammatory and autoimmune diseases, including [[rheumatoid arthritis]], [[psoriasis]], and [[multiple sclerosis]]. It promotes inflammation by inducing the production of pro-inflammatory cytokines and chemokines, leading to the recruitment and activation of immune cells.
+The IL-17 family consists of six cytokines, each with distinct roles in immune regulation:
-== Structure ==
+* '''IL-17A''': The most studied member, involved in autoimmune diseases and chronic inflammatory conditions.
+* '''IL-17B''': Less understood, but implicated in inflammatory responses.
+* '''IL-17C''': Plays a role in epithelial cell responses to infection.
+* '''IL-17D''': Involved in the regulation of [[innate immunity]].
+* '''IL-17E (IL-25)''': Promotes [[Th2 cell]] responses and is involved in allergic reactions.
+* '''IL-17F''': Similar to IL-17A, involved in mucosal immunity.
-IL-17 is a homodimeric protein composed of two identical subunits. Each subunit consists of a single polypeptide chain that is folded into a unique cysteine-knot structure. This structure is shared by all members of the IL-17 family, which includes six cytokines (IL-17A to IL-17F).
+== Clinical Significance ==
-== Clinical significance ==
+[[File:IL17F_1JPY.png|thumb|left|Another view of IL-17F structure]]
-Due to its role in inflammation and autoimmune diseases, IL-17 has become a target for therapeutic intervention. Several drugs that inhibit the activity of IL-17 or block its receptor have been developed and approved for the treatment of psoriasis, psoriatic arthritis, and ankylosing spondylitis. These drugs have shown efficacy in reducing the symptoms of these diseases, but they can also have side effects, including an increased risk of infections.
+IL-17 has been implicated in a variety of [[autoimmune diseases]], including [[rheumatoid arthritis]], [[psoriasis]], and [[multiple sclerosis]]. It is also associated with chronic inflammatory conditions such as [[inflammatory bowel disease]] (IBD). Targeting IL-17 with specific [[monoclonal antibodies]] has become a therapeutic strategy in treating these diseases.
+== Related Pages ==
-== See also ==
-* [[Interleukin]]
 * [[Cytokine]]
-* [[T cell]]
+* [[T helper 17 cells]]
-* [[Neutrophil]]
+* [[Autoimmune disease]]
-* [[Rheumatoid arthritis]]
+* [[Inflammation]]
-* [[Psoriasis]]
-* [[Multiple sclerosis]]
-[[Category:Interleukins]]
+{{Cytokines}}
+[[Category:Immunology]]
 [[Category:Cytokines]]
-[[Category:Immunology]]
-{{Immunology-stub}}