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Revision as of 16:47, 10 February 2025
Estrone phosphate is a natural, steroidal estrogen and a phosphoric acid ester of estrone that is formed in the liver and that circulates in the blood. It is one of the three major naturally occurring estrogens, the others being estradiol and estriol.
Chemistry
Estrone phosphate, also known as estrone 3-phosphate, is a synthetic, steroidal estrogen and a phosphoric acid ester of estrone. It is an estrogen ester and a prodrug of estrone in the body. Estrone phosphate is a white or almost white, crystalline powder or colorless crystals. It is practically insoluble in water, freely soluble in ethanol (96 per cent) and in methanol, sparingly soluble in acetone.
Pharmacology
Estrone phosphate is a prodrug of estrone, and is converted into estrone in the body. It has a much longer duration of action and half-life than estrone due to its improved lipid solubility and resistance to metabolism.
Medical uses
Estrone phosphate is used in hormone therapy for menopausal symptoms and low estrogen levels in women, and in hormone therapy for transgender women.
Side effects
Like all estrogens, estrone phosphate has a variety of potential side effects, including nausea, vomiting, fluid retention, edema, weight gain, breast tenderness, headaches, and mood changes.
See also
| Estrogens and antiestrogens |
| Estrogens |
|
| ER
agonists | * Steroidal: Alfatradiol
- Certain androgens/anabolic steroids (e.g., testosterone, testosterone esters, methyltestosterone, metandienone, nandrolone esters) (via estrogenic metabolites)
- Certain progestins (e.g., norethisterone, noretynodrel, etynodiol diacetate, tibolone)
- Clomestrone
- Cloxestradiol acetate
- Conjugated estriol
- Conjugated estrogens
- Epiestriol
- Epimestrol
- Esterified estrogens
- Estetrol†
- Estradiol
- Estradiol esters (e.g., estradiol acetate, estradiol benzoate, estradiol cypionate, estradiol enanthate, estradiol undecylate, estradiol valerate, polyestradiol phosphate, estradiol ester mixtures (Climacteron))
- Estramustine phosphate
- Estriol
- Estriol esters (e.g., estriol succinate, polyestriol phosphate)
- Estrogenic substances
- Estrone
- Estrone esters
- Ethinylestradiol#
- Hydroxyestrone diacetate
- Mestranol
- Methylestradiol
- Moxestrol
- Nilestriol
- Prasterone (dehydroepiandrosterone; DHEA)
- Promestriene
- Quinestradol
- Quinestrol
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| Progonadotropins | |
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| Antiestrogens |
|
ER
antagonists
(incl. SERMs
/SERDs
) | |
| Aromatase inhibitors | |
| Antigonadotropins | * Androgens/ anabolic steroids (e.g., testosterone, testosterone esters, nandrolone esters, oxandrolone, fluoxymesterone)
- D2 receptor antagonists (prolactin releasers) (e.g., domperidone, metoclopramide, risperidone, haloperidol, chlorpromazine, sulpiride)
- GnRH
agonists (e.g., leuprorelin, goserelin)
- GnRH
antagonists (e.g., cetrorelix, elagolix)
- Progestogens (e.g., chlormadinone acetate, cyproterone acetate, gestonorone caproate, hydroxyprogesterone caproate, medroxyprogesterone acetate, megestrol acetate)
|
| Others | * Mixed mechanism of action: Danazol
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