CXCL5

CXCL5 is a small cytokine belonging to the CXC chemokine family that is also known as epithelial-derived neutrophil-activating peptide 78 (ENA-78). It is produced following stimulation of cells such as epithelial cells, platelets, and monocytes with the inflammatory cytokines interleukin-1 or tumor necrosis factor-alpha. Expression of this gene is also induced by epidermal growth factor.

Function

CXCL5 is a chemotactic agent for neutrophil granulocytes. It attracts these cells by interacting with the cell surface chemokine receptor CXCR2. Its gene is located in a cluster of other chemokines on chromosome 4q13.3 in humans.

Clinical significance

CXCL5 has been implicated in various inflammatory and cancer-related conditions. It is associated with inflammatory diseases such as rheumatoid arthritis, lung fibrosis, and atherosclerosis. In cancer, it has been shown to promote angiogenesis, tumor growth, and metastasis.

See also

• CXC chemokine
• Chemokine
• Neutrophil granulocytes
• CXCR2

References

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External links

• CXCL5 at the US National Library of Medicine Medical Subject Headings (MeSH)

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