Siklós

Siklós
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Routes of administration	Oral
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Siklós is a brand name for the drug hydroxyurea, which is used primarily in the treatment of sickle cell disease. It is an antineoplastic agent that works by inhibiting the synthesis of DNA, thereby reducing the frequency of painful crises and the need for blood transfusions in patients with sickle cell disease.

Medical Uses

Siklós is indicated for the management of sickle cell anemia in adults, adolescents, and children over the age of two. It helps to increase fetal hemoglobin (HbF) levels, which reduces the sickling of red blood cells and improves overall blood flow.

Mechanism of Action

Hydroxyurea, the active ingredient in Siklós, works by inhibiting the enzyme ribonucleotide reductase, which is crucial for DNA synthesis. This inhibition leads to an increase in fetal hemoglobin production, which in turn reduces the sickling of red blood cells and decreases the occurrence of vaso-occlusive events.

Side Effects

Common side effects of Siklós include bone marrow suppression, which can lead to neutropenia, thrombocytopenia, and anemia. Other side effects may include gastrointestinal disturbances, skin reactions, and hair loss.

Dosage and Administration

Siklós is administered orally, and the dosage is typically based on the patient's weight and clinical response. Regular monitoring of blood counts is essential to adjust the dose and minimize the risk of adverse effects.

Contraindications

Siklós is contraindicated in patients with severe bone marrow depression, known hypersensitivity to hydroxyurea, and during pregnancy due to potential teratogenic effects.

Monitoring

Patients on Siklós require regular monitoring of blood counts, renal function, and liver function tests to detect any potential toxicities early.

See Also

• Sickle cell disease
• Hydroxyurea
• Antineoplastic agents

References

• Hydroxyurea Monograph
• Clinical Review of Hydroxyurea

External Links

• Sickle Cell Disease on WikiMD
• Hydroxyurea on WikiMD

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