Estradiol anthranilate

From Food & Medicine Encyclopedia

Estradiol anthranilate, also known as estradiol 3-anthranilate, is a synthetic, steroidal estrogen that is a derivative of estradiol, the primary female sex hormone. It is an estrogen ester, specifically, the 3-anthranilic acid ester of estradiol. Estradiol anthranilate was never marketed.

Chemistry[edit]

Estradiol anthranilate, also known as estra-1,3,5(10)-triene-3,17β-diol 3-anthranilate, is a synthetic estrane steroid and a derivative of estradiol. It is more specifically a derivative of estradiol in which the C3 hydroxyl group has been modified into an anthranilic acid ester.

Pharmacology[edit]

As an estrogen, estradiol anthranilate has similar effects in the body to those of natural estrogens. It can stimulate the development of female secondary sexual characteristics, regulate the menstrual cycle, and influence mood and cognitive function. However, as a synthetic derivative of estradiol, it may have different pharmacokinetics and potency.

History[edit]

Estradiol anthranilate was synthesized in the 1950s as part of a series of estradiol esters. Despite its synthesis, it was never marketed for medical use.

See also[edit]

Estrogens and antiestrogens

ER agonists

* Steroidal: Alfatradiol

Certain androgens/anabolic steroids (e.g., testosterone, testosterone esters, methyltestosterone, metandienone, nandrolone esters) (via estrogenic metabolites)
Certain progestins (e.g., norethisterone, noretynodrel, etynodiol diacetate, tibolone)
Clomestrone
Cloxestradiol acetate
Conjugated estriol
Conjugated estrogens
Epiestriol
Epimestrol
Esterified estrogens
Estetrol^†
Estradiol
Estradiol esters (e.g., estradiol acetate, estradiol benzoate, estradiol cypionate, estradiol enanthate, estradiol undecylate, estradiol valerate, polyestradiol phosphate, estradiol ester mixtures (Climacteron))
Estramustine phosphate
Estriol
Estriol esters (e.g., estriol succinate, polyestriol phosphate)
Estrogenic substances
Estrone
Estrone esters
- Estrone sulfate
- Estropipate (piperazine estrone sulfate)
Ethinylestradiol^#
- Ethinylestradiol sulfonate
Hydroxyestrone diacetate
Mestranol
Methylestradiol
Moxestrol
Nilestriol
Prasterone (dehydroepiandrosterone; DHEA)
- Prasterone enanthate
- Prasterone sulfate
Promestriene
Quinestradol
Quinestrol

Progonadotropins

* Antiandrogens (e.g., bicalutamide)

GnRH agonists (e.g., GnRH (gonadorelin), leuprorelin)
Gonadotropins (e.g., FSH

, LH

)

ER antagonists (incl. SERMs /SERDs )	* Acolbifene^† Anordrin Bazedoxifene Broparestrol Clomifene^# Cyclofenil Enclomifene^† Epitiostanol Lasofoxifene Mepitiostane Ormeloxifene Ospemifene Raloxifene Tamoxifen^# Toremifene Exclusively antagonistic: Elacestrant Fulvestrant Noncompetitive inhibitors: Trilostane
Aromatase inhibitors	* First-generation: Aminoglutethimide Testolactone Second-generation: Fadrozole Formestane Third-generation: Anastrozole Exemestane Letrozole
Antigonadotropins	* Androgens/anabolic steroids (e.g., testosterone, testosterone esters, nandrolone esters, oxandrolone, fluoxymesterone) D₂ receptor antagonists (prolactin releasers) (e.g., domperidone, metoclopramide, risperidone, haloperidol, chlorpromazine, sulpiride) GnRH agonists (e.g., leuprorelin, goserelin) GnRH antagonists (e.g., cetrorelix, elagolix) Progestogens (e.g., chlormadinone acetate, cyproterone acetate, gestonorone caproate, hydroxyprogesterone caproate, medroxyprogesterone acetate, megestrol acetate)
Others	* Mixed mechanism of action: Danazol Gestrinone Androstenedione immunogens: Androvax (androstenedione albumin) Ovandrotone albumin (Fecundin)

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Estradiol_anthranilate[edit]

Estradiol anthranilate

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