Familiar chronic mucocutaneous candidiasis

Other Names: CMC; Chronic mucocutaneous candidiasis; Familial candidiasis

Chronic mucocutaneous candidosis (CMC) refers to a group of heterogenous disorders characterized by persistent, debilitating and/or recurrent infections of the skin, nails, and mucus membranes, mainly with the fungal pathogen Candida albicans.

Cause

Chronic mucocutaneous candidiasis can be inherited either autosomal dominant or autosomal recessive. There are 9 types of this condition with the first CANDF1 being located at 2p22.3-p21 (cytogenetically).

Symptoms and signs

The symptoms of this condition are hyperkeratosis, skin ulcer, dyspareunia, endocardium abnormality, vision problems, hepatitis, seizures, hematuria and meningitis.

Diagnosis

Chronic mucocutaneous candidiasis can be diagnosed in an affected individual via the following methods/tests:

• Thyroid function test
• Liver function test
• Cellular immunity test
• Skin biopsy
• Genetic testing

Treatment

Management for an individual with chronic mucocutaneous candidiasis consists of the following (relapse occurs once treatment is ceased, in many cases):

• Systemic antifungal therapy(e.g. Fluconazole)
• Transfer factor
• Combination therapy
• Screening (annually)

NIH genetic and rare disease info

• NIH info on Familiar chronic mucocutaneous candidiasis

Familiar chronic mucocutaneous candidiasis is a rare disease.

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