FOSB
FOSB
FOSB (pronounced /fɒsb/), also known as FBJ murine osteosarcoma viral oncogene homolog B, is a gene that encodes a protein known as FosB. This protein is a member of the Fos family of transcription factors, which are involved in cellular functions such as proliferation, differentiation, and transformation.
Etymology
The term "FOSB" is derived from the name of the FBJ murine osteosarcoma virus, which was first identified in the 1980s. The "B" in FOSB refers to the specific variant of the Fos protein that the gene encodes.
Function
The FOSB gene is involved in several important cellular processes. It is a part of the AP-1 transcription factor complex, which regulates gene expression in response to a variety of stimuli, including cytokines, growth factors, stress, and bacterial and viral infections. The FosB protein can also form heterodimers with proteins from the Jun family, resulting in additional transcription factor complexes that can regulate gene expression.
Related Terms
- FOS: The gene that encodes the Fos protein, a member of the Fos family of transcription factors.
- Fos family: A family of transcription factors that includes Fos, FosB, FosL1, and FosL2.
- Transcription factor: A protein that binds to specific DNA sequences, thereby controlling the rate of transcription of genetic information from DNA to messenger RNA.
- AP-1 transcription factor: A transcription factor that regulates gene expression in response to a variety of stimuli.
- Jun family: A family of transcription factors that can form heterodimers with proteins from the Fos family.
External links
- Medical encyclopedia article on FOSB
- Wikipedia's article - FOSB
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