Transcription factor

Transcription Factor

Diagram illustrating the role of transcription factors in gene expression.

A transcription factor is a protein that regulates the transcription of genes by binding to specific DNA sequences. The primary function of transcription factors is to control the rate of transcription of genetic information from DNA to messenger RNA, thereby influencing cell function and development.

Function

Transcription factors are essential for the regulation of gene expression. They can act as activators or repressors of transcription. Activators enhance the interaction between RNA polymerase and a particular promoter, encouraging the transcription of the associated gene. Repressors, on the other hand, impede the interaction between RNA polymerase and the promoter, thereby inhibiting transcription.

Mechanism

Schematic representation of transcription factor binding to DNA.

Transcription factors typically contain one or more DNA-binding domains (DBDs), which attach to specific sequences of DNA adjacent to the genes they regulate. The binding of transcription factors to DNA can either promote or block the recruitment of RNA polymerase to specific genes. This process is often modulated by other proteins, such as coactivators or corepressors, which do not directly bind to DNA but influence transcription factor activity.

Types

There are several types of transcription factors, categorized based on their structure and function. Some of the major classes include:

• Helix-turn-helix
• Zinc finger
• Leucine zipper
• Helix-loop-helix

Each class has a distinct DNA-binding domain that determines its specific interaction with DNA.

Role in Development and Disease

Transcription factors play a crucial role in cell differentiation and development. They are involved in the regulation of genes that control cell growth, division, and apoptosis. Abnormalities in transcription factor function can lead to diseases such as cancer, where the regulation of cell proliferation is disrupted.

Examples

Structure of the LacI dimer, a well-studied transcription factor.

One well-known example of a transcription factor is the lac repressor in Escherichia coli, which regulates the lac operon. Another example is the p53 protein, which acts as a tumor suppressor by regulating the cell cycle and preventing cancer.

Related Pages

• Gene expression
• RNA polymerase
• DNA-binding domain
• Gene regulation

References

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  Transcription Factors Diagram

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  Transcription Factor Schematic

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  LacI Dimer Structure Annotated

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  Transcription Factors DNA Binding Sites