SLC22A3
SLC22A3, also known as the Solute Carrier Family 22 Member 3, is a protein that in humans is encoded by the SLC22A3 gene. It is a member of the organic cation transporter family, which is involved in the transport of various endogenous and exogenous compounds.
Function
The SLC22A3 protein is an integral membrane protein that is involved in the transport of small molecules. This protein can transport a broad range of cations and is involved in the reabsorption of cations in the kidneys. It is also involved in the transport of organic cations in the liver and intestine.
Clinical significance
Mutations in the SLC22A3 gene have been associated with various diseases, including Parkinson's disease, Epilepsy, and Cancer. In particular, it has been found that the SLC22A3 gene is frequently mutated in esophageal squamous cell carcinoma.
See also
References
External links
- SLC22A3 at the US National Library of Medicine Medical Subject Headings (MeSH)
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Contributors: Prab R. Tumpati, MD
